Human metabolite detection by surface-enhanced Raman spectroscopy.
Human metabolite detection by surface-enhanced Raman spectroscopy.
复制标题
通过表面增强拉曼光谱检测人体代谢物
DOI：
10.1016/j.mtbio.2022.100205
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Ye J
中科院分区：
文献类型：
--
作者：
Lu Y;Lin L;Ye J
代谢产物是人体体液中重要的生物标志物，传递细胞活动和身体状况的直接信息。代谢物检测一直是生物医学领域的研究热点。表面增强拉曼光谱（Sers）是基于拉曼光谱的分子“指纹”和等离子体纳米材料的巨大信号增强（低至单分子水平），已被证明是一种新颖而强大的代谢物检测工具。Sers具有超灵敏、无标记、快速、特异和非破坏性等优点。本文综述了近10年来基于SERS的细胞水平、组织水平、生物流体水平内源性代谢物以及生物流体中药物代谢物的检测研究进展。对Sers技术在代谢物检测中的挑战和优化方法进行了详细的讨论。展望了Sers与现代生物医学技术的结合。
Metabolites are important biomarkers in human body fluids, conveying direct information of cellular activities and physical conditions. Metabolite detection has long been a research hotspot in the field of biology and medicine. Surface-enhanced Raman spectroscopy (SERS), based on the molecular “fingerprint” of Raman spectrum and the enormous signal enhancement (down to a single-molecule level) by plasmonic nanomaterials, has proven to be a novel and powerful tool for metabolite detection. SERS provides favorable properties such as ultra-sensitive, label-free, rapid, specific, and non-destructive detection processes. In this review, we summarized the progress in recent 10 years on SERS-based sensing of endogenous metabolites at the cellular level, in tissues, and in biofluids, as well as drug metabolites in biofluids. We made detailed discussions on the challenges and optimization methods of SERS technique in metabolite detection. The combination of SERS with modern biomedical technology were also anticipated.
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影响因子：
6.1
作者：
Choi, Charles J.;Wu, Hsin-Yu;Cunningham, Brian T.
通讯作者：
Cunningham, Brian T.
影响因子：
2.1
作者：
Falamas, A.;Rotaru, H.;Hedesiu, M.
通讯作者：
Hedesiu, M.
影响因子：
4.7
作者：
Dastmalchi F;Deleyrolle LP;Karachi A;Mitchell DA;Rahman M
通讯作者：
Rahman M
可再生 SERS 纳米尖揭示单细胞氧化应激事件
影响因子：
8.9
作者：
Chen, Jiamin;Wang, Jiaqi;Xu, Shuping
通讯作者：
Xu, Shuping
DOI：
10.1007/978-1-4939-2377-9_13
发表时间：
2015-01-01
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Emwas, Abdul-Hamid M
通讯作者：
Emwas, Abdul-Hamid M