Time trends of cancer mortality among elderly in Italy, 1970-2008: an observational study.
Time trends of cancer mortality among elderly in Italy, 1970-2008: an observational study.
复制标题
DOI：
10.1186/1471-2407-12-443
复制
发表时间：
2012-10-02
期刊：
影响因子：
3.8
通讯作者：
Serraino D
中科院分区：
文献类型：
--
作者：
Bidoli E;Fratino L;Bruzzone S;Pappagallo M;De Paoli P;Tirelli U;Serraino D
意大利人口的老龄化必然会导致越来越多的人被诊断出患有癌症。在过去的四十年中，意大利老年人（65-84岁）癌症死亡率的负担还没有进行全面的描述。癌症死亡率被用来描述1970-2008年间的时间趋势。由意大利国家统计研究所提供的死亡率计数根据数据可用性进行分组：1970-74年至1995-99年的五年期，以及2000-03年和2006-08年的组。按日历期间计算了1995-2008年期间老年人和中年人（35-64岁）的标准化比率（世界人口），同时计算了年百分比变化（APC）。老年人癌症死亡人数在1970-74年（男性31，400人死亡/年，女性24，000人）和2006-08年（男性63，000人死亡/年，女性42，000人）之间几乎翻了一番。总的癌症死亡率在1985- 1989年和1990- 1994年的五年期间达到高峰（男子约为1，500/100，000，妇女约为680/100，000），此后有所下降。在1995-2008年期间，男性癌症死亡率每年下降1.6%，女性每年下降0.9%。这些下降主要是由男性胃癌、膀胱癌、前列腺癌和肺癌（APC分别为-3.3%、-2.7%、-2.5%、-2.2%）以及女性胃癌、膀胱癌和乳腺癌（APC分别为-3.5%、-1.9%、-1.1%）驱动的。相反，1995年至2008年期间，女性肺癌（APC = +0.6%）、男性皮肤黑色素瘤（APC = +1.7%）和胰腺癌（APC = +0.6%男性和+0.9%女性）的死亡率增加。1995年至2008年期间，在意大利老年人中观察到癌症死亡率的总体有利趋势。早期诊断、提高抗癌治疗的疗效和合并症的管理是这些积极观察结果的最可能解释。然而，针对最常见的风险因素（如吸烟），早期诊断和获得护理的持久预防性干预措施应该重新考虑和扩展，以匹配老年人与中年人记录的癌症死亡率的降低。
The aging of the Italian population will unavoidably lead to a growing number of persons diagnosed and living with cancer. A comprehensive description of the burden of cancer mortality among Italian elderly (65-84 years of age) in the last four decades has not been carried out yet. Cancer mortality rates were used to describe time trends between 1970-2008. Mortality counts, provided by the Italian National Institute of Statistics, were grouped according to data availability: in quinquennia from 1970-74 through 1995-99, and in 2000-03 and 2006-08 groups. Age-standardized rates (world population) were computed by calendar periods while annual percent changes (APCs) were computed for elderly and middle aged (35-64 years) people for the period 1995-2008. The number of cancer deaths in elderly nearly doubled between 1970-74 (31,400 deaths/year in men, and 24,000 in women) and 2006-08 (63,000 deaths/year in men, and 42,000 in women). Overall cancer mortality rates peaked during the quinquennia 1985-89 and 1990-94 (about 1,500/100,000 in men and 680 in women) and declined thereafter. Throughout 1995-2008 cancer mortality rates decreased by -1.6%/year in men and -0.9%/year in women. These decreases were mainly driven by cancers of the stomach, bladder, prostate, and lung (APC = -3.3%, -2.7%, -2.5%, -2.2%, respectively) in men, and by cancers of the stomach, bladder, and breast (APC = -3.5%, -1.9%, -1.1%, respectively) in women. Conversely, increases in mortality rates between 1995 and 2008 were recorded for lung cancer (APC = +0.6%) in women, cutaneous melanoma (APC = +1.7%) in men, and pancreatic cancer (APC = +0.6% in men and +0.9% in women). Overall favorable trends in cancer mortality were observed among Italian elderly between 1995 and 2008. Early diagnosis, improved efficacy of anti-cancer treatments and management of comorbidities are the most likely explanations of these positive observations. However, enduring preventive interventions against the most common risk factor (e.g. cigarette smoking), early diagnosis, and access to care should be reconsidered and extended to match the reductions of cancer mortality recorded in the elderly with those in the middle aged.
登录
查看更多内容
影响因子：
50.5
作者：
Yang, L.;Fujimoto, J.;Sakamoto, N.
通讯作者：
Sakamoto, N.
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
50.5
作者：
Pelucchi, C.;Tramacere, I.;La Vecchia, C.
通讯作者：
La Vecchia, C.
影响因子：
2.3
作者：
Lubin, Jay H.;Muscat, Joshua;Gaudet, Mia M.;Olshan, Andrew F.;Curado, Maria Paula;Dal Maso, Luigino;Wuensch-Filho, Victor;Sturgis, Erich M.;Szeszenia-Dabrowska, Neonilia;Castellsague, Xavier;Zhang, Zuo-Feng;Smith, Elaine;Fernandez, Leticia;Matos, Elena;Franceschi, Silvia;Fabianova, Eleonora;Rudnai, Peter;Purdue, Mark P.;Mates, Dana;Wei, Qingyi;Herrero, Rolando;Kelsey, Karl;Morgenstern, Hal;Shangina, Oxana;Koifman, Sergio;Lissowska, Jolanta;Levi, Fabio;Daudt, Alexander W.;Eluf Neto, Jose;Chen, Chu;Lazarus, Philip;Winn, Deborah M.;Schwartz, Stephen M.;Boffetta, Paolo;Brennan, Paul;Menezes, Ana;La Vecchia, Carlo;McClean, Michael;Talamini, Renato;Rajkumar, Thangarajan;Hayes, Richard B.;Hashibe, Mia
通讯作者：
Hashibe, Mia
影响因子：
2.4
作者：
Arfe, Andrea;Malvezzi, Matteo;Negri, Eva
通讯作者：
Negri, Eva