Effects of pore size, implantation time, and nano-surface properties on rat skin ingrowth into percutaneous porous titanium implants.
Effects of pore size, implantation time, and nano-surface properties on rat skin ingrowth into percutaneous porous titanium implants.
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DOI：
10.1002/jbm.a.34807
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发表时间：
2014-05
影响因子：
4.9
通讯作者：
Pitkin, Mark
中科院分区：
文献类型：
--
作者：
Farrell, Brad J.;Prilutsky, Boris I.;Ritter, Jana M.;Kelley, Sean;Popat, Ketul;Pitkin, Mark
经皮骨结合种植体的主要问题是皮肤-种植体结合不良，这可能导致感染。本研究研究了孔径（小，40-100微米和大，100-160微米）、纳米管表面处理（纳米）和植入持续时间（3周和6周）对皮肤长入多孔钛的影响。将每种类型的植入物永久插入35只随机分配到7组的大鼠的背部。每周测量植入物挤出率，并在收获植入物后通过组织学确定皮肤长入植入物。结果发现，所有3种类型的植入物均显示皮肤组织向内生长超过皮肤下总植入物多孔面积的30%（第3周）和50%（第4-6周）;植入时间越长，皮肤向内生长越多（p<0.05）。仅观察到1例感染（感染率2.9%）。小型组和纳米组显示出相同的植入物挤出率，低于大型组的挤出率（0.06±0.01 vs. 0.16 ± 0.02 cm/周; p<0.05）。小号、大号和纳米植入物的向内生长面积相当。然而，从质量上讲，纳米植入物在前三周内表现出最大的细胞抑制。我们得出结论，经皮多孔钛植入物允许皮肤整合，具有安全密封的潜力。
The main problem of percutaneous osseointegrated implants is poor skin-implant integration, which may cause infection. This study investigated the effects of pore size (Small, 40–100 microns and Large, 100–160 microns), nanotubular surface treatment (Nano), and duration of implantation (3 and 6 weeks) on skin ingrowth into porous titanium. Each implant type was percutaneously inserted in the back of 35 rats randomly assigned to 7 groups. Implant extrusion rate was measured weekly and skin ingrowth into implants was determined histologically after harvesting implants. It was found that all 3 types of implants demonstrated skin tissue ingrowth of over 30% (at week 3) and 50% (at weeks 4–6) of total implant porous area under the skin; longer implantation resulted in greater skin ingrowth (p<0.05). Only one case of infection was observed (infection rate 2.9%). Small and Nano groups showed the same implant extrusion rate which was lower than the Large group rate (0.06±0.01 vs. 0.16 ± 0.02 cm/week; p<0.05). Ingrowth area was comparable in the Small, Large and Nano implants. However, qualitatively, the Nano implants showed greatest cellular inhabitation within first three weeks. We concluded that percutaneous porous titanium implants allow for skin integration with the potential for a safe seal.
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DOI：
10.1002/jbm.820240303
发表时间：
1990-03-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
JANSEN, JA;VANDERWAERDEN, JPCM;DEGROOT, K
通讯作者：
DEGROOT, K
DOI：
10.1682/jrrd.2006.12.0160
发表时间：
2007-01-01
影响因子：
--
作者：
Pitkin, Mark;Raykhtsaum, Grigory;Duz, Volodimir
通讯作者：
Duz, Volodimir
影响因子：
9.7
作者：
Puckett, Sabrina D.;Lee, Phin Peng;Webster, Thomas J.
通讯作者：
Webster, Thomas J.
DOI：
10.3109/02844318209006565
发表时间：
1982-01-01
影响因子：
--
作者：
BRANEMARK, PI;ALBREKTSSON, T
通讯作者：
ALBREKTSSON, T
影响因子：
4.9
作者：
Chou, Teri G. Rosenbaum;Petti, Cathy A.;Bloebaum, Roy D.
通讯作者：
Bloebaum, Roy D.