Dietary intakes of berries and flavonoids in relation to cognitive decline.
Dietary intakes of berries and flavonoids in relation to cognitive decline.
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DOI：
10.1002/ana.23594
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发表时间：
2012-07
影响因子：
11.2
通讯作者：
Grodstein, Francine
中科院分区：
文献类型：
--
作者：
Devore, Elizabeth E.;Kang, Jae Hee;Breteler, Monique M. B.;Grodstein, Francine
浆果富含类黄酮，特别是花青素，在实验研究中可以提高认知能力。我们前瞻性地评估了浆果和黄酮类化合物的长期摄入量是否与老年妇女认知能力下降的速度较慢有关。从1980年开始，每四年对护士健康研究的参与者进行一次半定量的食物频率问卷调查。在1995-2001年，我们开始测量16，010名年龄≥70岁的参与者的认知功能;随访评估进行了两次，间隔两年。为了确定长期饮食，我们通过最初的认知访谈对1980年以来的饮食变量进行了平均。使用多变量调整的混合线性回归，我们估计了长期浆果和类黄酮摄入量的认知下降斜率的平均差异。蓝莓和草莓的摄入量越大，认知能力下降的速度越慢（例如，对于平均所有六项认知测试的总体评分，对于蓝莓：比较极端摄入类别的p趋势=0.014和平均差异=0.04 [95% CI=0.01，0.07];对于草莓：p趋势= 0.022，平均差异=0.03 [95% CI=0.00，0.06]，比较极端摄入类别）。这些效应估计值与我们在队列中发现的大约1.5至2.5岁的效应估计值相当，表明浆果摄入似乎可以将认知衰老延迟长达2.5年。此外，在进一步的支持性证据中，花青素和总黄酮的摄入量增加与认知能力下降的速度较慢相关（p趋势分别为0.015和0.053，对于整体评分）。更高的类黄酮摄入量，特别是来自浆果的类黄酮，似乎可以降低老年人认知能力下降的速度。
Berries are high in flavonoids, especially anthocyanidins, and improve cognition in experimental studies. We prospectively evaluated whether greater long-term intakes of berries and flavonoids are associated with slower rates of cognitive decline in older women. Beginning in 1980, a semi-quantitative food frequency questionnaire was administered every four years to Nurses’ Health Study participants. In 1995–2001, we began measuring cognitive function in 16,010 participants, aged ≥70 years; follow-up assessments were conducted twice, at two-year intervals. To ascertain long-term diet, we averaged dietary variables from 1980 through the initial cognitive interview. Using multivariable-adjusted, mixed linear regression, we estimated mean differences in slopes of cognitive decline by long-term berry and flavonoid intakes. Greater intakes of blueberries and strawberries were associated with slower rates of cognitive decline (e.g., for a global score averaging all six cognitive tests, for blueberries: p-trend=0.014 and mean difference=0.04 [95% CI=0.01, 0.07] comparing extreme categories of intake; for strawberries: p-trend= 0.022 and mean difference=0.03 [95% CI=0.00, 0.06] comparing extreme categories of intake), after adjusting for multiple potential confounders. These effect estimates were equivalent to those we find for approximately 1.5 to 2.5 years of age in our cohort, indicating that berry intake appears to delay cognitive aging by up to 2.5 years. Additionally, in further supporting evidence, greater intakes of anthocyanidins and total flavonoids were associated with slower rates of cognitive decline (p-trends= 0.015 and 0.053, respectively, for the global score). Higher intake of flavonoids, particularly from berries, appears to reduce rates of cognitive decline in older adults.
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影响因子：
4.2
作者：
Joseph, James A.;Shukitt-Hale, Barbara;Willis, Lauren M.
通讯作者：
Willis, Lauren M.
影响因子：
5
作者：
Letenneur, L.;Proust-Lima, C.;Barberger-Gateau, P.
通讯作者：
Barberger-Gateau, P.
影响因子：
14.5
作者：
BADDELEY, AD;BRESSI, S;SPINNLER, H
通讯作者：
SPINNLER, H
影响因子：
6.1
作者：
Krikorian R;Shidler MD;Nash TA;Kalt W;Vinqvist-Tymchuk MR;Shukitt-Hale B;Joseph JA
通讯作者：
Joseph JA
影响因子：
3.6
作者：
Andres-Lacueva, C;Shukitt-Hale, B;Joseph, JA
通讯作者：
Joseph, JA