Blueberry supplementation improves memory in older adults.
Blueberry supplementation improves memory in older adults.
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DOI：
10.1021/jf9029332
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发表时间：
2010-04-14
影响因子：
6.1
通讯作者：
Joseph JA
中科院分区：
文献类型：
--
作者：
Krikorian R;Shidler MD;Nash TA;Kalt W;Vinqvist-Tymchuk MR;Shukitt-Hale B;Joseph JA
随着老年人口的增加，痴呆症的患病率也在增加。在缺乏有效治疗的情况下，预防方法对于解决这一公共卫生问题至关重要。蓝莓含有多酚类化合物，最突出的是花青素，具有抗氧化和抗炎作用。此外，花青素还与大脑中心的神经元信号传导增加有关，这些神经元信号传导介导记忆功能以及改善葡萄糖处置，这些益处有望减轻神经变性。我们研究了每天饮用野生蓝莓汁对9名老年人早期记忆变化的影响。在12周时，我们观察到配对联想学习（p = 0.009）和单词列表回忆（p = 0.04）有所改善。此外，有趋势表明抑郁症状减轻（p = 0.08）和血糖水平降低（p = 0.10）。我们还比较了蓝莓受试者的记忆表现与人口统计学匹配的样本谁消耗了浆果安慰剂饮料在同伴试验相同的设计，并观察到配对关联学习的可比结果。这项初步研究的结果表明，中期蓝莓补充剂可以赋予神经认知益处，并为更全面的人体试验奠定基础，以研究预防潜力和神经机制。
The prevalence of dementia is increasing with expansion of the older adult population. In the absence of effective therapy, preventive approaches are essential to address this public health problem. Blueberries contain polyphenolic compounds, most prominently anthocyanins, which have antioxidant and anti-inflammatory effects. In addition, anthocyanins have been associated with increased neuronal signaling in brain centers mediating memory function as well as improved glucose disposal, benefits that would be expected to mitigate neurodegeneration. We investigated the effects of daily consumption of wild blueberry juice in a sample of nine older adults with early memory changes. At 12 weeks, we observed improved paired associate learning (p = 0.009) and word list recall (p = 0.04). In addition, there were trends suggesting reduced depressive symptoms (p = 0.08) and lower glucose levels (p = 0.10). We also compared the memory performances of the blueberry subjects with a demographically-matched sample who consumed a berry placebo beverage in a companion trial of identical design and observed comparable results for paired associate learning. The findings of this preliminary study suggest that moderate-term blueberry supplementation can confer neurocognitive benefit and establish a basis for more comprehensive human trials to study preventive potential and neuronal mechanisms.
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影响因子：
5
作者：
Letenneur, L.;Proust-Lima, C.;Barberger-Gateau, P.
通讯作者：
Barberger-Gateau, P.
影响因子：
7.1
作者：
O'Byrne, DJ;Devaraj, S;Jialal, I
通讯作者：
Jialal, I
影响因子：
3.6
作者：
Casadesus, G;Shukitt-Hale, B;Joseph, JA
通讯作者：
Joseph, JA
影响因子：
3.6
作者：
Andres-Lacueva, C;Shukitt-Hale, B;Joseph, JA
通讯作者：
Joseph, JA
影响因子：
4.2
作者：
Craft, S
通讯作者：
Craft, S