One-pot synthesis of gold nanostars using plant polyphenols for cancer photoacoustic imaging and photothermal therapy

One-pot synthesis of gold nanostars using plant polyphenols for cancer photoacoustic imaging and photothermal therapy
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利用植物多酚一锅合成金纳米星用于癌症光声成像和光热治疗

DOI:
10.1007/s11051-016-3483-1
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发表时间:
2016-06
影响因子:
2.5
通讯作者:
Liu Jingfeng
Liu Jingfeng
中科院分区:
材料科学4区
文献类型:
--
作者:
Zhang Xiao-Long;Zheng Cheng;Zhang Yun;Yang Huang-Hao;Liu Xiaolong;Liu Jingfeng

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已经发现分支等离子体纳米结构在其多分支花瓣周围表现出强烈的电磁场增强。这一特性赋予了它们在催化、表面增强拉曼散射、光声成像和光热治疗方面的改进性能。尽管已经开发了几种合成技术,但精确控制高度支化的纳米结构的生长与一锅无表面活性剂的程序仍然是具有挑战性的。在此,我们提出了一个简单的无籽路线,合成金纳米星(AuNS)使用天然植物多酚,没食子酸(GA),作为还原剂和稳定剂。AuNS的大小和形状可以通过简单地调节添加的GA的量来调整。在最佳条件下制备的纳米金具有较强的近红外吸收、良好的光热效率和良好的生物相容性,粒径约为100 nm。我们证明了AuNS可以用于活癌细胞中的同时光声成像和光热治疗。这项研究强调了容易合成的AuNS可以作为癌症诊断和治疗的有前途的平台。
Branched plasmonic nanostructures have been found to exhibit strong enhancement of the electromagnetic field surrounding their multi-branched petals. This feature endows them with improved performance in catalysis, surface-enhanced Raman scattering, photoacoustic imaging, and photothermal therapy. Albeit several synthesis techniques have been developed, the precisely controlled growth of highly branched nanostructures with a one-pot surfactant-free procedure is still challenging. Herein, we present a simple seedless route to synthesize gold nanostars (AuNSs) using a natural plant polyphenol, gallic acid (GA), as a reducing and stabilizing agent. The size and shape of AuNSs can be tuned by simply adjusting the amount of added GA. Under the optimum condition, the as-prepared AuNSs with diameters about 100 nm exhibit strong near-infrared absorption, good photothermal efficiency, and high biocompatibility. We demonstrate that AuNSs can be utilized for simultaneous photoacoustic imaging and photothermal therapy in living cancer cells. This study highlights facile synthesized AuNSs could serve as a promising platform for cancer diagnosis and therapy.
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