Gut microbiome composition is associated with spatial structuring and social interactions in semi-feral Welsh Mountain ponies.
Gut microbiome composition is associated with spatial structuring and social interactions in semi-feral Welsh Mountain ponies.
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DOI：
10.1186/s40168-018-0593-2
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发表时间：
2018-11-22
期刊：
影响因子：
15.5
通讯作者：
Shultz S
中科院分区：
文献类型：
--
作者：
Antwis RE;Lea JMD;Unwin B;Shultz S
微生物组组成与宿主功能性状有关，包括代谢和免疫功能。微生物组组成的驱动因素越来越多地得到表征;然而，组水平微生物组趋同的证据是有限的，并且可能代表多水平特征（即跨个体和组），从而遗传表型受到社会互动的影响。在这里，我们调查的影响，空间结构和社会互动的肠道微生物组成的威尔士山地小马。我们发现，半野生小马表现出的微生物群组成的变化，根据乐队（组）成员，除了相当大的个体内的变化。空间结构也被确定在乐队内，这表明，尽管社区生活，社会行为仍然影响微生物组的组成。事实上，我们表明特定的相互作用（即母亲-后代和种马-母马）导致更相似的微生物组，进一步支持了个体影响彼此的微生物组组成并最终影响群体的观点。马驹表现出与亚成体和成体不同的微生物组组成，最可能与饮食差异有关。我们提供了新的证据，表明微生物组组成在社会哺乳动物群体中的多个层次上结构化，因此可能形成一个选择可以发挥作用的单位。微生物组组成的高水平个体内变异，加上社会互动影响微生物组组成的潜力，表明微生物组选择的方向可能受到群体中个体成员的影响。虽然这一功能的影响需要进一步的研究，但这些结果支持了多级选择可以作用于微生物组的观点。本文的在线版本（10.1186/s40168-018-0593-2）包含补充材料，可供授权用户使用。
Microbiome composition is linked to host functional traits including metabolism and immune function. Drivers of microbiome composition are increasingly well-characterised; however, evidence of group-level microbiome convergence is limited and may represent a multi-level trait (i.e. across individuals and groups), whereby heritable phenotypes are influenced by social interactions. Here, we investigate the influence of spatial structuring and social interactions on the gut microbiome composition of Welsh mountain ponies. We show that semi-feral ponies exhibit variation in microbiome composition according to band (group) membership, in addition to considerable within-individual variation. Spatial structuring was also identified within bands, suggesting that despite communal living, social behaviours still influence microbiome composition. Indeed, we show that specific interactions (i.e. mother-offspring and stallion-mare) lead to more similar microbiomes, further supporting the notion that individuals influence the microbiome composition of one another and ultimately the group. Foals exhibited different microbiome composition to sub-adults and adults, most likely related to differences in diet. We provide novel evidence that microbiome composition is structured at multiple levels within populations of social mammals and thus may form a unit on which selection can act. High levels of within-individual variation in microbiome composition, combined with the potential for social interactions to influence microbiome composition, suggest the direction of microbiome selection may be influenced by the individual members present in the group. Although the functional implications of this require further research, these results lend support to the idea that multi-level selection can act on microbiomes. The online version of this article (10.1186/s40168-018-0593-2) contains supplementary material, which is available to authorized users.
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影响因子：
7.3
作者：
Arrieta MC;Stiemsma LT;Amenyogbe N;Brown EM;Finlay B
通讯作者：
Finlay B
影响因子：
9.8
作者：
Bordenstein SR;Theis KR
通讯作者：
Theis KR
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
15.5
作者：
Duranti S;Lugli GA;Mancabelli L;Armanini F;Turroni F;James K;Ferretti P;Gorfer V;Ferrario C;Milani C;Mangifesta M;Anzalone R;Zolfo M;Viappiani A;Pasolli E;Bariletti I;Canto R;Clementi R;Cologna M;Crifò T;Cusumano G;Fedi S;Gottardi S;Innamorati C;Masè C;Postai D;Savoi D;Soffiati M;Tateo S;Pedrotti A;Segata N;van Sinderen D;Ventura M
通讯作者：
Ventura M
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob