Resting-State Functional Connectivity of the Habenula in Mood Disorder Patients With and Without Suicide-Related Behaviors.
Resting-State Functional Connectivity of the Habenula in Mood Disorder Patients With and Without Suicide-Related Behaviors.
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DOI：
10.1176/appi.neuropsych.17120351
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Salas R
中科院分区：
文献类型：
--
作者：
Ambrosi E;Arciniegas DB;Curtis KN;Patriquin MA;Spalletta G;Sani G;Frueh BC;Fowler JC;Madan A;Salas R
缰核（Hb）是一个小的中脑结构，对于大脑信号和从负面事件中学习非常重要。因此，缰核与奖赏系统和运动区域都有着密切的联系。越来越多的证据表明缰核在精神疾病的病因学中起作用，包括情绪和物质使用障碍。然而，迄今为止还没有研究调查缰静息态功能连接（rsFC）在自杀相关行为（SB）。作者招募了123名患有重度抑郁症（MDD）或双相情感障碍（BD）并有自杀相关行为史（SB+）的个体，74名患有MDD或BD并有自杀意念史但无SB史（SB-）的个体，以及75名健康对照（HC）。使用基于种子的方法来鉴定显示具有Hb的不同rsFC的区域，然后进行ROI到ROI事后比较。与SB-和HC相比，SB+显示了左侧Hb与左侧海马旁回、右侧杏仁核、右侧中央前回和中央后回之间的更高连接性。与HC相比，心境障碍患者的左侧Hb与左侧颞中回、左侧角回与左侧后扣带回之间的rsFC较高，右侧Hb与左侧丘脑之间的rsFC较低。这些发现表明，血红蛋白参与自杀的神经回路。在SB+中发现的更高的缰rsFC可能介导将Hb与运动活动和上下文关联处理联系起来的机制中的功能障碍。
The habenula (Hb) is a small midbrain structure that is important for brain signaling and learning from negative events. Thus, the habenula is strongly connected to both the reward system and motor regions. Increasing evidence suggests a role for the habenula in the etiology of psychiatric disorders, including mood and substance use disorders. However, no studies to date have investigated habenular resting-state functional connectivity (rsFC) in suicide-related behaviors (SB). The authors enrolled 123 individuals with major depressive disorder (MDD) or bipolar disorder (BD) and a history of suicide-related behaviors (SB+), 74 individuals with MDD or BD and a history of suicide ideation but no history of SB (SB−), and 75 healthy controls (HC). A seed-based approach was used to identify regions showing different rsFC with the Hb followed by ROI-to-ROI post-hoc comparisons. Compared to both SB− and HC, SB+ showed higher connectivity between the left Hb and the left parahippocampal gyrus, the right amygdala, and the right precentral and postcentral gyri. Patients with mood disorders displayed higher rsFC between the left Hb and left middle temporal gyrus, the left angular gyrus and the left posterior cingulate cortex as well as lower rsFC between the right Hb and the left thalamus, when compared to HC. These findings suggest that the Hb is involved in the neural circuitry of suicide. The higher habenular rsFC found in the SB+ may mediate a dysfunction in the mechanism that links the Hb with motor activity and contextual associative processing.
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