Relationships between aeroallergen levels and hospital admissions for asthma in the Brussels-Capital Region: a daily time series analysis.
Relationships between aeroallergen levels and hospital admissions for asthma in the Brussels-Capital Region: a daily time series analysis.
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DOI：
10.1186/s12940-018-0378-x
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发表时间：
2018-04-11
期刊：
影响因子：
--
通讯作者：
Van Nieuwenhuyse A
中科院分区：
文献类型：
--
作者：
Guilbert A;Cox B;Bruffaerts N;Hoebeke L;Packeu A;Hendrickx M;De Cremer K;Bladt S;Brasseur O;Van Nieuwenhuyse A
在人群水平上，室外花粉粒和真菌孢子浓度与严重哮喘急性发作相关。然而，每个分类群的具体影响和空气污染对这些症状的伴随影响仍有待更好地表征。这项研究旨在调查布鲁塞尔首都地区（比利时）各种空气过敏原的环境浓度与哮喘相关住院之间的短期相关性，该地区的入院率特别高。基于哮喘住院的管理记录和对11种树木/草本花粉分类群和2种真菌孢子分类群的定期监测，进行了涵盖2008-2013年期间的每日时间序列分析。通过将准泊松回归与分布滞后模型相结合，调整季节性和长期趋势、星期几、公共假日、平均温度和相对湿度，捕获暴露后长达6天的影响。通过年龄和空气污染（PM，NO2，O3）的影响修改进行了测试。观察到草（5.9%，95% CI：0.0，12.0）、桦树（3.2%，95% CI：1.1，5.3）和角木（0.7%，95% CI：0.2，1.3）花粉浓度四分位数范围增加导致哮喘住院率显著增加。对于几个类群，包括草，年龄修改的效果是显着的，住院的风险往往是更高的个人年龄小于60岁。空气污染物也影响了这种关系：在PM10和O3浓度分别较高的情况下，草和桦树花粉浓度的风险似乎更大。这些发现表明空气中的草、桦树和角树花粉与布鲁塞尔地区的严重哮喘恶化有关。这些化合物似乎与空气污染协同作用，更具体地影响年轻人和中年人。这些危及生命的事件中的大多数在理论上可以通过改善疾病诊断/管理和有针对性的沟通行动来预防。本文的在线版本（10.1186/s12940-018-0378-x）包含补充材料，可供授权用户使用。
Outdoor pollen grain and fungal spore concentrations have been associated with severe asthma exacerbations at the population level. The specific impact of each taxon and the concomitant effect of air pollution on these symptoms have, however, still to be better characterized. This study aimed to investigate the short-term associations between ambient concentrations of various aeroallergens and hospitalizations related to asthma in the Brussels-Capital Region (Belgium), an area recording especially high rates of admissions. Based on administrative records of asthma hospitalizations and regular monitoring of 11 tree/herbaceous pollen taxa and 2 fungal spore taxa, daily time series analyses covering the 2008–2013 period were performed. Effects up to 6 days after exposure were captured by combining quasi-Poisson regression with distributed lag models, adjusting for seasonal and long-term trends, day of the week, public holidays, mean temperature and relative humidity. Effect modification by age and air pollution (PM, NO2, O3) was tested. A significant increase in asthma hospitalizations was observed for an interquartile range increase in grass (5.9%, 95% CI: 0.0, 12.0), birch (3.2%, 95% CI: 1.1, 5.3) and hornbeam (0.7%, 95% CI: 0.2, 1.3) pollen concentrations. For several taxa including grasses, an age modification effect was notable, the hospitalization risk tending to be higher in individuals younger than 60 years. Air pollutants impacted the relationships too: the risk appeared to be stronger for grass and birch pollen concentrations in case of high PM10 and O3 concentrations respectively. These findings suggest that airborne grass, birch and hornbeam pollen are associated with severe asthma exacerbations in the Brussels region. These compounds appear to act in synergy with air pollution and to more specifically affect young and intermediate age groups. Most of these life-threatening events could theoretically be prevented with improved disease diagnosis/management and targeted communication actions. The online version of this article (10.1186/s12940-018-0378-x) contains supplementary material, which is available to authorized users.
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影响因子：
12.4
作者：
D'Amato, G
通讯作者：
D'Amato, G
DOI：
10.1164/rccm.201405-0901pp
发表时间：
2015-01-01
影响因子：
24.7
作者：
Feldman, Amy S.;He, Yuan;Hartert, Tina V.
通讯作者：
Hartert, Tina V.
影响因子：
10
作者：
Anderson, HR;de Leon, AP;Strachan, DP
通讯作者：
Strachan, DP
影响因子：
5.6
作者：
Cakmak, S;Dales, RE;Coates, F
通讯作者：
Coates, F
影响因子：
4.9
作者：
Atkinson, R. W.;Strachan, D. P.;Emberlin, J.
通讯作者：
Emberlin, J.