Nocturnal blood pressure dipping in treated hypertensives: insights from the SPRINT trial.
Nocturnal blood pressure dipping in treated hypertensives: insights from the SPRINT trial.
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接受治疗的高血压患者夜间血压下降：来自 SPRINT 试验的见解。
DOI：
10.1093/eurjpc/zwaa125
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发表时间：
2022
影响因子：
8.3
通讯作者：
Arora,Pankaj
中科院分区：
文献类型：
--
作者：
Parcha,Vibhu;Kalra,Rajat;Li,Peng;Oparil,Suzanne;Arora,Garima;Arora,Pankaj
与日间或门诊血压相比，夜间血压（BP）是不良心血管事件发生的更强预测因子。1动态血压监测（ABPM）有助于识别高风险的夜间血压表型，如夜间血压的非下降和上升模式。这些模式与终末器官损伤增加相关，并可预测临床BP以上的不良心血管事件。1，2我们试图评估“治疗期间”高风险夜间收缩压表型对SyrinBP干预试验（SPRINT）ABPM辅助研究参与者的预后影响。1，3 SPRINT试验的详细研究入选和排除标准以及ABPM评估的详细信息已在先前描述。1分析的研究数据可在NHLBI BioLINCC数据库下载。参与者被分为高风险[非浸渍或立管（平均夜间-白天比率：> 0.9）]或低风险（平均夜间-白天比率：<0.9）。9)夜间收缩压2临床/亚临床心血管疾病定义为以下一种或多种病史：心肌梗死、急性冠脉综合征、冠状动脉血运重建、颈动脉血运重建、外周动脉疾病伴血运重建、冠状动脉/颈动脉/下肢动脉狭窄> 50%;腹主动脉瘤> _50 mm，冠状动脉钙化评分> _400，踝臂指数< _0。90，即左心室肥大。通过图形可视化和Shapiro-Wilk检验评估数据正态性。使用v2和Wilcoxon秩和检验，使用描述性统计量总结基线特征。研究结局为不良心血管事件的发生，包括首次发生心肌梗死、未导致心肌梗死的急性冠脉综合征、卒中、急性失代偿性心力衰竭或心血管原因死亡。使用Poisson回归计算发生率。高危和低危人群心血管不良事件累积发生率曲线
Nocturnal blood pressure (BP) is a stronger predictor of the development of adverse cardiovascular events in comparison with daytime or clinic BP. 1 Ambulatory BP monitoring (ABPM) helps to identify high-risk nocturnal BP phenotypes, such as non-dipping and riser pattern of nocturnal BP. These patterns are associated with increased end-organ damage and are predictive of adverse cardiovascular events above and beyond clinic BP. 1, 2 We sought to evaluate the prognostic implications of ‘on-treatment’high-risk nocturnal systolic BP phenotypes in the participants of the Systolic BP Intervention Trial (SPRINT) ABPM ancillary study. 1, 3 The detailed study inclusion and exclusion criteria of the SPRINT trial and the details of the ABPM assessment have been previously described. 1 Anonymized study data are publically available for download at the NHLBI BioLINCC Data Repository. The participants were stratified as having high-risk [non-dipping or riser (average nighttime-daytime ratio:> 0.9)] or low-risk (average nighttimedaytime ratio:< _0. 9) nocturnal systolic BP. 2 Clinical/subclinical cardiovascular disease was defined as history of one or more of the following: myocardial infarction, acute coronary syndrome, coronary revascularization, carotid revascularization, peripheral arterial disease with revascularization,> 50% stenosis of coronary/carotid/lower extremity artery; abdominal aortic aneurysm> _50 mm, coronary artery calcium score> _400, ankle-brachial index< _0. 90, or left ventricular hypertrophy.The data normality was assessed through graphical visualization and using Shapiro–Wilk test. The baseline characteristics were summarized with descriptive statistics using the v2 and Wilcoxon rank-sum tests. The study outcome was the development of adverse cardiovascular events, which was a composite of the first occurrence of myocardial infarction, acute coronary syndrome not resulting in myocardial infarction, stroke, acute decompensated heart failure, or death from cardiovascular causes. The incidence rates were computed using Poisson regression. The cumulative incidence curves of adverse cardiovascular events in those with high-risk and low-risk
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DOI：
10.4269/ajtmh.1963.12.103
发表时间：
1963
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
J. F. Kent;E. H. Fife
通讯作者：
E. H. Fife
人类免疫球蛋白基因分型的一种新的快速方法。
影响因子：
4.4
作者：
Girish N. Vyas;H. Fudenberg;H. M. Pretty;E. Gold
通讯作者：
E. Gold
反复化脓性感染患者的选择性 γ-g 球蛋白缺乏。
DOI：
10.1056/nejm197009172831205
发表时间：
1970
期刊：
The New England journal of medicine
影响因子：
--
作者：
P. Schur;H. Borel;E. Gelfand;C. Alper;F. Rosen
通讯作者：
F. Rosen
尿苷单磷酸激酶 3：B 型流感嗜血杆菌疾病易感性的遗传标记
DOI：
--
发表时间：
1985
期刊：
The Lancet
影响因子：
--
作者：
G. Petersen;E. Scott;J. Rotter;D. Silimperi;D. Hall;J. Ward
通讯作者：
J. Ward
DOI：
10.1001/jama.238.7.604
发表时间：
1977
期刊：
JAMA
影响因子：
--
作者：
Charles M. Ginsburg;George H. McCracken;Sharon Rae;James C. Parke
通讯作者：
James C. Parke