Single cell transcriptomic representation of social dominance in prefrontal cortex and the influence of preweaning maternal and postweaning social environment.
Single cell transcriptomic representation of social dominance in prefrontal cortex and the influence of preweaning maternal and postweaning social environment.
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DOI：
10.1038/s41598-024-52200-6
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发表时间：
2024-01-25
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
社会支配包括赢得二元竞争和优先获得资源和繁殖。支配地位受环境因素的影响，特别是在产后早期和青春期。去抑制性内侧前额叶皮层（mPFC）微回路与小鼠“试管试验”社会竞争范式中的优势表达有关，但优势背后的神经可塑性尚不清楚。我们之前报道过，通过身体活动（轮转，而不是久坐不动）饲养的雄性幼崽表现出试管测试优势和更高的生殖适应性，在这里我们表明，与断奶的社会隔离也增加了优势。通过使用单细胞转录组学，我们测试了这些模型中显性增加是否与mPFC中一种或多种细胞类型的特定转录谱有关。断奶前的母体效应导致锥体神经元基因表达改变，而断奶后的社会孤立没有影响。然而，母亲运动和社会隔离的影响均诱导了小白蛋白阳性（PV）中间神经元突触通道、受体和粘附基因的协同下调，表明优势的发展伴随着PV中间神经元介导的锥体细胞抑制的受损。这项研究可能有助于了解环境诱导的PFC转录可塑性及其与试管测试优势的关系。
Social dominance encompasses winning dyadic contests and gaining priority access to resources and reproduction. Dominance is influenced by environmental factors, particularly during early postnatal life and adolescence. A disinhibitory medial prefrontal cortex (mPFC) microcircuit has been implicated in the expression of dominance in the “tube test” social competition paradigm in mice, but the neuroplasticity underlying dominance is not known. We previously reported that male pups raised by physically active (wheel-running, as opposed to sedentary) dams exhibit tube test dominance and increased reproductive fitness, and here we show that social isolation from weaning also increases dominance. By using single cell transcriptomics, we tested if increased dominance in these models is associated with a specific transcriptional profile in one or more cell-types in the mPFC. The preweaning maternal effect, but not postweaning social isolation, caused gene expression changes in pyramidal neurons. However, both the effect of maternal exercise and social isolation induced the coordinated downregulation of synaptic channel, receptor, and adhesion genes in parvalbumin positive (PV) interneurons, suggesting that development of dominance is accompanied by impaired PV interneuron-mediated inhibition of pyramidal cells. This study may help understand environmentally induced transcriptional plasticity in the PFC and its relationship to tube test dominance.
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影响因子：
2.3
作者：
Morandotti, Niccolo;Dima, Danai;Brambilla, Paolo
通讯作者：
Brambilla, Paolo
DOI：
10.1111/gbb.12731
发表时间：
2022-03
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Fulenwider HD;Caruso MA;Ryabinin AE
通讯作者：
Ryabinin AE
DOI：
10.1073/pnas.1121251109
发表时间：
2012-10-16
影响因子：
11.1
作者：
Kolb, Bryan;Mychasiuk, Richelle;Gibb, Robbin
通讯作者：
Gibb, Robbin
影响因子：
2.7
作者：
Kunkel, Thaddeus;Wang, Hongbing
通讯作者：
Wang, Hongbing
影响因子：
56.9
作者：
DESJARDINS, C;MARUNIAK, JA;BRONSON, FH
通讯作者：
BRONSON, FH