Peripheral and spinal mechanisms of acupoint sensitization phenomenon.
Peripheral and spinal mechanisms of acupoint sensitization phenomenon.
复制标题
穴位敏化现象的外周及脊髓机制
DOI：
10.1155/2013/742195
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Zhu B
中科院分区：
文献类型：
--
作者：
Rong PJ;Li S;Ben H;Li L;Yu LL;Cui CX;Li X;Zhu B
本研究以成年雌性SD大鼠为实验动物，观察结肠输入炎症刺激性芥子油引起体表炎症反应的部位、大小及敏感性变化。采用结肠直肠扩张（CRD）作为内脏伤害性刺激，记录脊髓L1-L3节段背角宽动态范围（WDR）神经元的活动。本研究还观察了不同强度CRD刺激前后电针足三里-上巨虚穴对WDR神经元的激活作用以及刺激与反应的量效关系。结果表明，在内脏炎症的情况下，体表神经源性反应的渗出点数量随着内脏炎症的严重程度沿着增加（Li et al. 2006）。随着内脏炎症反应的增强，WDR神经元的外周感受野面积也沿着增大。电针对WDR神经元的激活作用与内脏炎症的严重程度呈正相关。因此，我们认为内脏伤害性刺激可以使穴位的功能敏感化。当内脏器官功能受损时，体表反应点的数量、穴位感受野的大小和穴位的敏感性也随之改变。
This study was carried out on adult female Sprague-Dawley rats to observe the position, size, and sensitivity change of inflammatory reactions on body surfaces induced by colorectal import of inflammatory irritant mustard oil. Colorectal distension (CRD) was adopted as a visceral noxious stimulus to record the activities of spinal dorsal horn wide-dynamic range (WDR) neurons activities at spinal segments L1–L3. The study also observed the activations of WDR neurons by electro-acupuncture (EA) on acupoints of Zusanli-Shangjuxu before and after different intensities of CRD stimulation and the dose-response relationship between stimulus and response. The results show that in the case of visceral inflammation, the number of exudation points of neurogenic reaction on body surfaces increased along with the severity of visceral inflammation (Li et al. 2006). The area of peripheral receptive fields of WDR neurons also enlarged along with the intensity of visceral inflammatory response. The activation effect of EA on WDR neurons was positively correlated with the severity of visceral inflammation. Therefore, we concluded that the function of acupoints can be sensitized by visceral noxious stimuli. When the function of internal organs was damaged, the number of reaction points on body surfaces, the size of acupoints' receptive fields, and the sensitivity of acupoints changed accordingly.
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DOI：
10.1155/2012/130802
发表时间：
2012
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Ben H;Li L;Rong PJ;Jin ZG;Zhang JL;Li YH;Li X
通讯作者：
Li X
影响因子：
7.4
作者：
NESS, TJ;METCALF, AM;GEBHART, GF
通讯作者：
GEBHART, GF
影响因子：
2.5
作者：
Carpenter, KJ;Nandi, M;Dickenson, AH
通讯作者：
Dickenson, AH
影响因子：
2.9
作者：
Zhu, B;Xu, WD;Gao, XY
通讯作者：
Gao, XY
影响因子：
64.5
作者：
Story, GM;Peier, AM;Patapoutian, A
通讯作者：
Patapoutian, A