Carbon Dots as an Emergent Class of Antimicrobial Agents.
Carbon Dots as an Emergent Class of Antimicrobial Agents.
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DOI：
10.3390/nano11081877
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发表时间：
2021-07-22
期刊：
影响因子：
--
通讯作者：
Galan MC
中科院分区：
文献类型：
--
作者：
Ghirardello M;Ramos-Soriano J;Galan MC
抗生素耐药性是公认的全球性挑战。细菌检测工具可以通过促进循证抗生素处方来对抗抗生素耐药性，从而避免过度处方，这有助于耐药性的传播。不幸的是，传统的基于培养的鉴定方法至少需要一天的时间，而新兴的替代方法受到高成本和熟练操作人员要求的限制。此外，光敏剂促进细菌的光动力灭活可以被认为是对抗多药耐药病原体的最有前途的策略之一。在这种情况下，碳量子点（CD）已被确定为一类有前途的光敏剂纳米材料，用于特异性检测和灭活不同的细菌物种。CD具有特殊的和可调的化学和光电性质，使其成为抗菌治疗诊断应用的优秀候选者，例如高化学稳定性，高水溶性，低毒性和优异的生物相容性。在这篇综述中，我们将总结最新的进展，使用CD作为抗菌剂，包括最常用的方法CD和CD/复合材料的合成和他们的抗菌性能在体外和体内模型在过去的3年中开发。
Antimicrobial resistance is a recognized global challenge. Tools for bacterial detection can combat antimicrobial resistance by facilitating evidence-based antibiotic prescribing, thus avoiding their overprescription, which contributes to the spread of resistance. Unfortunately, traditional culture-based identification methods take at least a day, while emerging alternatives are limited by high cost and a requirement for skilled operators. Moreover, photodynamic inactivation of bacteria promoted by photosensitisers could be considered as one of the most promising strategies in the fight against multidrug resistance pathogens. In this context, carbon dots (CDs) have been identified as a promising class of photosensitiser nanomaterials for the specific detection and inactivation of different bacterial species. CDs possess exceptional and tuneable chemical and photoelectric properties that make them excellent candidates for antibacterial theranostic applications, such as great chemical stability, high water solubility, low toxicity and excellent biocompatibility. In this review, we will summarize the most recent advances on the use of CDs as antimicrobial agents, including the most commonly used methodologies for CD and CD/composites syntheses and their antibacterial properties in both in vitro and in vivo models developed in the last 3 years.
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