Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms.
Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms.
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DOI：
10.3390/ijms19092703
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发表时间：
2018-09-11
影响因子：
5.6
通讯作者：
Choi BY
中科院分区：
文献类型：
--
作者：
Choi BY
头皮头发的功能不仅是保护免受太阳辐射和热/冷暴露，而且还有助于一个人的外观和个性。渐进性脱发具有美容和社会影响。毛发经历毛发周期的三个阶段：生长期、退化期和休止期。通过周期性的损失和新的头发生长，头发的数量保持相对恒定。多种因素，如激素，营养状况，暴露于辐射，环境毒物和药物，可能会影响头发生长。雄激素是导致雄激素性脱发的最重要因素。其他形式的脱发包括免疫原性脱发，即斑秃。虽然许多疗法，如芬必得和米诺地尔，是批准的药物，和其他一些（例如，托法替尼）的研究正在进行中，各种各样的结构不同类别的植物化学物质，包括人参中存在的那些，已经在大量的临床前研究中证明了促进毛发生长的作用。本文综述了人参及其代谢产物在预防脱发方面的作用及其机制。
The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one’s appearance and personality. Progressive hair loss has a cosmetic and social impact. Hair undergoes three stages of hair cycle: the anagen, catagen, and telogen phases. Through cyclical loss and new-hair growth, the number of hairs remains relatively constant. A variety of factors, such as hormones, nutritional status, and exposure to radiations, environmental toxicants, and medications, may affect hair growth. Androgens are the most important of these factors that cause androgenic alopecia. Other forms of hair loss include immunogenic hair loss, that is, alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are approved medications, and a few others (e.g., tofacitinib) are in progress, a wide variety of structurally diverse classes of phytochemicals, including those present in ginseng, have demonstrated hair growth-promoting effects in a large number of preclinical studies. The purpose of this review is to focus on the potential of ginseng and its metabolites on the prevention of hair loss and its underlying mechanisms.
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影响因子：
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作者：
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