The joint effect of ambient air pollution and agricultural pesticide exposures on lung function among children with asthma.
The joint effect of ambient air pollution and agricultural pesticide exposures on lung function among children with asthma.
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DOI：
10.1016/j.envres.2020.109903
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发表时间：
2020-11
影响因子：
8.3
通讯作者：
Magzamen S
中科院分区：
文献类型：
--
作者：
Benka-Coker W;Hoskovec L;Severson R;Balmes J;Wilson A;Magzamen S
环境污染物已被证明对易感人群的呼吸健康有不利影响。然而，同时暴露于多种不同的环境污染物的作用知之甚少。我们采用了一种多领域、多污染物的方法来评估儿童肺功能指标与选定的环境空气污染物和农药之间的关系。利用美国环保署和加州农药使用登记处的数据，我们重建了美国加利福尼亚州圣华金谷153名轻度间歇性或轻度持续性哮喘儿童三个月前暴露于环境空气污染物（臭氧（O3）、二氧化氮（NO2）、空气动力学中位直径< 2.5μm的颗粒物（PM2.5）和< 10μm的颗粒物（PM10））和农药(有机磷（OP）、氨基甲酸酯（C)和甲基溴（MeBr））的情况。我们采用贝叶斯核机回归（BKMR）来估计同时暴露于空气污染物和农药与肺功能测量（1秒用力呼气量（FEV1）、用力肺活量（FVC）和用力呼气流量在25%至75%之间（FEF25-75））之间的关系。在BKMR分析中，混合物（污染物和杀虫剂）的总体影响与FEV1和FVC的减少有关，特别是当所有环境暴露都高于其第60百分位数时。例如，在第70百分位（与中位数相比），整体混合物对FEV1的影响为- 0.12SD (- 50mL, 95% CI: - 180mL, 90mL)，对FVC的影响为- 0.18SD （- 90mL, 95% CI: - 240mL, 60mL）。然而，所有联合效应估计的95%可信区间都包含零值。在这个农业-城市界面，我们观察到多污染物分析的结果，表明随着环境空气污染物和农业农药的累积增加，对一些儿科肺功能测量产生不利影响。考虑到效应估计的不确定性，这种方法应该在更大规模的研究中进行探索。
Ambient environmental pollutants have been shown to adversely affect respiratory health in susceptible populations. However, the role of simultaneous exposure to multiple diverse environmental pollutants is poorly understood. We applied a multidomain, multipollutant approach to assess the association between pediatric lung function measures and selected ambient air pollutants and pesticides. Using data from the US EPA and California Pesticide Use Registry, we reconstructed three months prior exposure to ambient air pollutants ((ozone (O3), nitrogen dioxide (NO2), particulate matter with a median aerodynamic diameter < 2.5μm (PM2.5) and < 10μm (PM10)) and pesticides (organophosphates (OP), carbamates (C) and methyl bromide (MeBr)) for 153 children with mild intermittent or mild persistent asthma from the San Joaquin Valley of California, USA. We implemented Bayesian kernel machine regression (BKMR) to estimate the association between simultaneous exposures to air pollutants and pesticides and lung function measures (forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and forced expiratory flow between 25% and 75% of vital capacity (FEF25–75)). In BKMR analysis, the overall effect of mixtures (pollutants and pesticides) was associated with reduced FEV1 and FVC, particularly when all the environmental exposures were above their 60th percentile. For example, the effect of the overall mixture at the 70th percentile (compared to the median) was a −0.12SD (−50mL, 95% CI: −180mL, 90mL) change in the FEV1 and a −0.18SD (−90mL, 95% CI: −240mL, 60mL) change in the FVC. However, 95% credible intervals around all of the joint effect estimates contained the null value. At this agricultural-urban interface, we observed results from multipollutant analyses, suggestive of adverse effects on some pediatric lung function measures following a cumulative increase in ambient air pollutants and agricultural pesticides. Given the uncertainty in effect estimates, this approach should be explored in larger studies.
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影响因子：
10.4
作者：
Claus Henn B;Schnaas L;Ettinger AS;Schwartz J;Lamadrid-Figueroa H;Hernández-Avila M;Amarasiriwardena C;Hu H;Bellinger DC;Wright RO;Téllez-Rojo MM
通讯作者：
Téllez-Rojo MM
影响因子：
11.8
作者：
Coker E;Chevrier J;Rauch S;Bradman A;Obida M;Crause M;Bornman R;Eskenazi B
通讯作者：
Eskenazi B
影响因子：
2.4
作者：
Benka-Coker, Wande;Loftus, Christine;Magzamen, Sheryl
通讯作者：
Magzamen, Sheryl
影响因子：
168.9
作者：
Guarnieri, Michael;Balmes, John R.
通讯作者：
Balmes, John R.
DOI：
10.1152/ajplung.00343.2003
发表时间：
2004-05-01
影响因子：
4.9
作者：
Fryer, AD;Lein, PJ;Jett, DA
通讯作者：
Jett, DA