Otoacoustic emissions, auditory evoked potentials and self-reported gender in people affected by disorders of sex development (DSD).
Otoacoustic emissions, auditory evoked potentials and self-reported gender in people affected by disorders of sex development (DSD).
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DOI：
10.1016/j.yhbeh.2014.07.004
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发表时间：
2014-08
影响因子：
3.5
通讯作者：
McFadden, Dennis
中科院分区：
文献类型：
--
作者：
Wisniewski, Amy B.;Espinoza-Varas, Blas;Aston, Christopher E.;Edmundson, Shelagh;Champlin, Craig A.;Pasanen, Edward G.;McFadden, Dennis
关键词：
耳声发射(OAEs)和听觉诱发电位(AEP)都是性二态的，都被认为是受产前雄激素暴露的影响。OAEs和AEP来自以下三种性发育障碍(DSD)中的一种--(1)女性完全雄激素不敏感综合征(CAIS)；(2)先天性肾上腺增生症(CAH)；(3)患有46，XY DSD的个体，包括产前暴露的雄激素，尽管最初的抚养方式是女性(男性DSD)，但仍发展为男性。使用标准化问卷对性别认同(GI)和角色(GR)进行了回溯性和参与研究时的测量。这项研究的主要目的是确定DSD患者和对照组的耳声发射和听觉诱发电位的模式是否与性别相关。第二个目标是评估OAE和AEP模式是否根据产前雄激素暴露的不同而不同。对照男性、患有DSD的男性和患有CAH的女性比对照女性和患有CAI的女性产生更少的自发OAE(SOAE)--这是男性的典型模式。此外，在所有被测试的群体中，产生的国有企业数量与性别发展相关。尽管在对照组男性和女性之间观察到了一些AEP的性别差异，但AEP的测量与性别发展无关，也不随DSD患者产前雄激素暴露的程度而变化。因此，OAEs，而不是AEPs，可能被证明是评估DSD患者早期大脑暴露于雄激素和预测性别发育的生物测试有用的。
Both otoacoustic emissions (OAEs) and auditory evoked potentials (AEPs) are sexually dimorphic, and both are believed to be influenced by prenatal androgen exposure. OAEs and AEPs were collected from people affected by 1 of 3 categories of disorders of sex development (DSD) – (1) women with complete androgen insensitivity syndrome (CAIS); (2) women with congenital adrenal hyperplasia (CAH); and (3) individuals with 46, XY DSD including prenatal androgen exposure who developed a male gender despite initial rearing as females (men with DSD). Gender identity (GI) and role (GR) were measured both retrospectively and at the time of study participation, using standardized questionnaires. The main objective of this study was to determine if patterns of OAEs and AEPs correlate with gender in people affected by DSD and in controls. A second objective was to assess if OAE and AEP patterns differed according to degrees of prenatal androgen exposure across groups. Control males, men with DSD, and women with CAH produced fewer spontaneous OAEs (SOAEs) – the male-typical pattern – than control females and women with CAIS. Additionally, the number of SOAEs produced correlated with gender development across all groups tested. Although some sex differences in AEPs were observed between control males and females, AEP measures did not correlate with gender development, nor did they vary according to degrees of prenatal androgen exposure, among people with DSD. Thus, OAEs, but not AEPs, may prove useful as bioassays for assessing early brain exposure to androgens and predicting gender development in people with DSD.
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影响因子：
2.8
作者：
McFadden, Dennis;Hsieh, Michelle D.;Garcia-Sierra, Adrian;Champlin, Craig A.
通讯作者：
Champlin, Craig A.
影响因子：
6.7
作者：
Kemp, DT
通讯作者：
Kemp, DT
影响因子：
6.1
作者：
Buck, JJ;Williams, RM;Acerini, CL
通讯作者：
Acerini, CL
影响因子：
3.7
作者：
DITTMANN, RW;KAPPES, MH;WALLIS, H
通讯作者：
WALLIS, H
影响因子：
2.4
作者：
Burns, Edward M.
通讯作者：
Burns, Edward M.