Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception.
Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception.
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DOI：
10.1038/s41467-018-03090-6
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发表时间：
2018-02-23
影响因子：
16.6
通讯作者：
Westmeyer GG
中科院分区：
文献类型：
--
作者：
Myklatun A;Lauri A;Eder SHK;Cappetta M;Shcherbakov D;Wurst W;Winklhofer M;Westmeyer GG
对某些物种如何感知地磁场（“磁感受”）的机械理解的障碍是缺乏表现出良好特征的磁感受行为并适合全脑分析的脊椎动物遗传模型。我们研究了遗传模式生物斑马鱼和青鳉，其年轻阶段是透明的，光学可访问的。在一个陌生的环境中，即使在黑暗中，成鱼也会根据磁场的方向变化来确定方向。为了在青少年中进行实验，我们施加了缓慢振荡的磁场，旨在在探索行为期间产生相互冲突的感觉输入。青鳉（但不是斑马鱼）在该测定中增加它们的运动活性。互补脑活动映射揭示了磁刺激过程中侧后脑神经元的激活。这些比较数据支持硬骨鱼类的磁感受，提供了光独立机制的证据，并证明了斑马鱼和青鳉作为遗传脊椎动物模型用于研究磁感受的生物物理和神经机制的有用性。动物磁感受的进展一直受到缺乏易处理的脊椎动物实验室模型的限制。在这里，作者证明了成熟的斑马鱼和青鳉的光独立磁感受，以及青鳉的磁敏感运动与侧后脑神经元激活相关。
An impediment to a mechanistic understanding of how some species sense the geomagnetic field (“magnetoreception”) is the lack of vertebrate genetic models that exhibit well-characterized magnetoreceptive behavior and are amenable to whole-brain analysis. We investigated the genetic model organisms zebrafish and medaka, whose young stages are transparent and optically accessible. In an unfamiliar environment, adult fish orient according to the directional change of a magnetic field even in darkness. To enable experiments also in juveniles, we applied slowly oscillating magnetic fields, aimed at generating conflicting sensory inputs during exploratory behavior. Medaka (but not zebrafish) increase their locomotor activity in this assay. Complementary brain activity mapping reveals neuronal activation in the lateral hindbrain during magnetic stimulation. These comparative data support magnetoreception in teleosts, provide evidence for a light-independent mechanism, and demonstrate the usefulness of zebrafish and medaka as genetic vertebrate models for studying the biophysical and neuronal mechanisms underlying magnetoreception. Advances in animal magnetoreception have been limited by a lack of tractable vertebrate laboratory models. Here, the authors demonstrate light-independent magnetoreception in mature zebrafish and medaka, as well as magnetosensitive locomotion in juvenile medaka associated with neuronal activation in the lateral hindbrain.
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DOI：
10.1073/pnas.1012185108
发表时间：
2011-01-18
影响因子：
11.1
作者：
Kinkhabwala, Amina;Riley, Michael;Fetcho, Joseph
通讯作者：
Fetcho, Joseph
影响因子：
3.6
作者：
Fame, Ryann M.;Brajon, Carole;Ghysen, Alain
通讯作者：
Ghysen, Alain
影响因子：
2.7
作者：
Avni, Reut;Zadicario, Pazit;Eilam, David
通讯作者：
Eilam, David
影响因子：
34.7
作者：
Erzurumlu, Reha S.;Murakami, Yasunori;Rijli, Filippo M.
通讯作者：
Rijli, Filippo M.
DOI：
10.1242/jeb.129411
发表时间：
2016-10-01
期刊：
The Journal of experimental biology
影响因子：
--
作者：
Herbert-Read JE
通讯作者：
Herbert-Read JE