Cognition in older adults with bipolar disorder versus major depressive disorder.
Cognition in older adults with bipolar disorder versus major depressive disorder.
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DOI：
10.1111/j.1399-5618.2012.00995.x
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发表时间：
2012-03
影响因子：
5.4
通讯作者：
Mulsant BH
中科院分区：
文献类型：
--
作者：
Gildengers AG;Butters MA;Chisholm D;Anderson SJ;Begley A;Holm M;Rogers JC;Reynolds CF 3rd;Mulsant BH
双相情感障碍（BD）和重度抑郁症（MDD）与老年人急性情绪发作和缓解状态期间的认知功能障碍相关。本报告的目的是首次调查BD和MDD老年人认知功能的相似性和差异，这可能揭示认知功能下降的机制。共评估了165例年龄≥65岁的BD（n = 43）或MDD（n = 122）受试者[平均值（SD）74.2（6.2）]，使用认知功能和认知工具性日常生活活动（C-IADL）的综合指标进行了胸腺功能正常评估。使用一组年龄和教育水平相当的心理健康个体（n = 92）对测试结果进行标准化。与对照组相比，BD和MDD受试者在所有认知领域均受损，最突出的是信息处理速度/执行功能。尽管具有较高的教育和较低的血管负荷的保护作用，BD受试者在所有认知领域的损害比MDD受试者。BD和MDD受试者的C-IADL无显著差异。在老年患者中，BD患者的总体认知功能比MDD患者差。我们的研究结果表明，BD的内在因素似乎与认知功能下降有关，并支持BD与认知功能下降相关的理解。
Bipolar disorder (BD) and major depressive disorder (MDD) are associated with cognitive dysfunction in older age during both acute mood episodes and remitted states. The purpose of this report is to investigate for the first time the similarities and differences in cognitive function of older adults with BD and MDD that may shed light on mechanisms of cognitive decline. A total of 165 subjects with BD (n = 43) or MDD (n = 122) ages ≥65 years [mean (SD) 74.2 (6.2)] were assessed when euthymic using comprehensive measures of cognitive function and cognitive-instrumental activities of daily living (C-IADLs). Test results were standardized using a group of mentally healthy individuals (n = 92) of comparable age and education level. Both subjects with BD and MDD were impaired across all cognitive domains compared to controls, most prominently in Information Processing Speed/Executive Function. Despite the protective effects of having higher education and lower vascular burden, BD subjects were more impaired across all cognitive domains compared with MDD subjects. Subjects with BD and MDD did not differ significantly in C-IADLs. In older age, patients with BD have worse overall cognitive function than patients with MDD. Our findings suggest that factors intrinsic to BD appear to be related to cognitive deterioration and support the understanding that BD is associated with cognitive decline.
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影响因子：
5.4
作者：
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通讯作者：
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影响因子：
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影响因子：
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