Coordinated regulation of chromatophore differentiation and melanogenesis during the ontogeny of skin pigmentation of Solea senegalensis (Kaup, 1858).
Coordinated regulation of chromatophore differentiation and melanogenesis during the ontogeny of skin pigmentation of Solea senegalensis (Kaup, 1858).
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DOI：
10.1371/journal.pone.0063005
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gisbert E
中科院分区：
文献类型：
--
作者：
Darias MJ;Andree KB;Boglino A;Fernández I;Estévez A;Gisbert E
塞内加尔鳎的异常色素沉着已被描述为其商业生产充分利用所面临的一个问题。为了提高我们对比目鱼这种重要商业物种的色素沉着的理解，我们评估了11个与色素沉着两个不同过程相关的基因：黑色素细胞分化和黑色素产生。基因表达峰的时间分布与色素沉着模式和皮肤黑化程度的变化相吻合。几个基因比率也进行了检查，把观点可能的遗传标记正常色素沉着发展的不同阶段。此外，在形态发生期间发生的表型变化与发生的基因表达的主要转变很好地对应。考虑到比目鱼所经历的显著的表型改变，包括眼侧和盲侧之间发生的不对称颜色，以及形态发生和色素沉着的两个过程的同行性，这些物种构成了研究色素沉着的一个有趣的模型。在这项研究中，我们提出了第一个近似解释塞内加尔鳎（Solea senegalensis）色素沉着个体发生调节的遗传机制。
Abnormal pigmentation of Senegalese sole has been described as one problem facing the full exploitation of its commercial production. To improve our understanding of flatfish pigmentation of this commercially important species we have evaluated eleven genes related to two different processes of pigmentation: melanophore differentiation, and melanin production. The temporal distribution of gene expression peaks corresponds well with changes in pigmentation patterns and the intensity of skin melanization. Several gene ratios were also examined to put in perspective possible genetic markers for the different stages of normal pigmentation development. Further, the phenotypic changes that occur during morphogenesis correspond well with the main transitions in gene expression that occur. Given the dramatic phenotypic alterations which flatfish undergo, including the asymmetric coloration that occurs between the ocular and the blind side, and the synchrony of the two processes of morphogenesis and pigmentation ontogenesis, these species constitute an interesting model for the study of pigmentation. In this study we present a first approximation towards explaining the genetic mechanisms for regulating pigmentation ontogeny in Senegalese sole, Solea senegalensis.
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影响因子：
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