WHOLE-BRAIN MAPPING OF AFFERENT PROJECTIONS TO THE BED NUCLEUS OF THE STRIA TERMINALIS IN TREE SHREWS
WHOLE-BRAIN MAPPING OF AFFERENT PROJECTIONS TO THE BED NUCLEUS OF THE STRIA TERMINALIS IN TREE SHREWS
复制标题
树鼩终纹床核传入投射的全脑映射
DOI：
10.1016/j.neuroscience.2016.07.017
复制
发表时间：
2016-10
期刊：
影响因子：
3.3
通讯作者：
Zhou Jiang Ning
中科院分区：
文献类型：
--
作者：
Ni Rong Jun;Luo Peng Hao;Shu Yu Mian;Chen Ju Tao;Zhou Jiang Ning
终纹床核（BST）在整合和传递输入信息到其他脑区以响应压力方面起着重要作用。在我们以前的出版物中已经全面描述了树（树鼩）BST的细胞结构。然而，以前的报告中没有说明向最佳技术小组提供的投入。本研究的目的是调查的传入投射到BST在整个脑树鼩使用逆行示踪剂荧光金（FG）的来源。目前的结果首次提供了树鼩大脑中BST投射神经元的详细全脑绘图。前额叶皮质、内嗅皮质、腹侧下托、杏仁核、腹侧被盖区和臂旁核是BST的密集神经支配区。此外，中度投射到BST起源于内侧视前区，乳头体上核，丘脑室旁核，脚桥被盖核，中缝背核，蓝斑和孤束核。在腹侧苍白球、斜角带核、丘脑腹后内侧核、丘脑后复合体、束间核、红核后野、横纹肌样核、中间网状核和小细胞网状核中确定了到BST的传入投射。此外，还分析了树鼩脑内不同区域BST投射神经元密度的差异。总之，全脑映射的直接输入到BST描绘在树。这些大脑回路涉及许多生理和行为过程的调节，包括压力，奖励，食物摄入和唤醒。
The bed nucleus of the stria terminalis (BST) plays an important role in integrating and relaying input information to other brain regions in response to stress. The cytoarchitecture of the BST in tree shrews (Tupaia belangeri chinensis) has been comprehensively described in our previous publications. However, the inputs to the BST have not been described in previous reports. The aim of the present study was to investigate the sources of afferent projections to the BST throughout the brain of tree shrews using the retrograde tracer Fluoro-Gold (FG). The present results provide the first detailed whole-brain mapping of BST-projecting neurons in the tree shrew brain. The BST was densely innervated by the prefrontal cortex, entorhinal cortex, ventral subiculum, amygdala, ventral tegmental area, and parabrachial nucleus. Moreover, moderate projections to the BST originated from the medial preoptic area, supramammillary nucleus, paraventricular thalamic nucleus, pedunculopontine tegmental nucleus, dorsal raphe nucleus, locus coeruleus, and nucleus of the solitary tract. Afferent projections to the BST are identified in the ventral pallidum, nucleus of the diagonal band, ventral posteromedial thalamic nucleus, posterior complex of the thalamus, interfascicular nucleus, retrorubral field, rhabdoid nucleus, intermediate reticular nucleus, and parvicellular reticular nucleus. In addition, the different densities of BST-projecting neurons in various regions were analyzed in the tree shrew brains. In summary, whole-brain mapping of direct inputs to the BST is delineated in tree shrews. These brain circuits are implicated in the regulation of numerous physiological and behavioral processes including stress, reward, food intake, and arousal.
登录
查看更多内容
影响因子：
3.1
作者：
Bienkowski, Michael S.;Rinaman, Linda
通讯作者：
Rinaman, Linda
影响因子：
3.3
作者：
B. Kapp;J. Schwaber;P. A. Driscoll
通讯作者：
B. Kapp;J. Schwaber;P. A. Driscoll
在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.5
作者：
Hsu, David T.;Price, Joseph L.
通讯作者：
Price, Joseph L.
DOI：
10.1523/jneurosci.6040-10.2011
发表时间：
2011-06-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Radley JJ;Sawchenko PE
通讯作者：
Sawchenko PE