Spectrotemporal dynamics of auditory cortical synaptic receptive field plasticity.
Spectrotemporal dynamics of auditory cortical synaptic receptive field plasticity.
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DOI：
10.1016/j.heares.2011.03.005
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发表时间：
2011-09
期刊：
影响因子：
2.8
通讯作者：
Martins, Ana Raquel O.
中科院分区：
文献类型：
--
作者：
Froemke, Robert C.;Martins, Ana Raquel O.
神经系统必须动态地呈现感觉信息，以便动物在复杂变化的环境中感知和操作。听觉皮层中的感受野可塑性允许皮层网络在出生后发育期间围绕感觉环境的显著特征进行组织，然后根据以后生活中的行为环境来完善这些表征。在这里，我们回顾了年轻和成年动物的听觉皮层感受野可塑性的主要特点，重点是修改频率调谐的突触输入。声输入模式的改变，包括感觉剥夺和音调暴露，导致兴奋性和抑制性强度的快速调整，这些强度共同决定了皮层神经元的阈上调谐曲线。长期的皮质可塑性也需要皮质下神经调节控制核团的共同激活，如胆碱能基底核，特别是在成年人中。无论发育阶段，抑制的调节似乎是一种普遍的机制，通过这种机制，感觉经验和神经调节状态的变化可以重塑皮层感受野。我们讨论了最近的研究结果表明，突触感受野可塑性的微观动力学展开作为一个多阶段的一组不同的现象，通过破坏兴奋和抑制之间的平衡，并最终导致大规模的变化，许多突触整个皮层。这些变化被协调以增强新的重要刺激的表征，可能用于改善人类的信号处理和语言学习。
The nervous system must dynamically represent sensory information in order for animals to perceive and operate within a complex, changing environment. Receptive field plasticity in the auditory cortex allows cortical networks to organize around salient features of the sensory environment during postnatal development, and then subsequently refine these representations depending on behavioral context later in life. Here we review the major features of auditory cortical receptive field plasticity in young and adult animals, focusing on modifications to frequency tuning of synaptic inputs. Alteration in the patterns of acoustic input, including sensory deprivation and tonal exposure, leads to rapid adjustments of excitatory and inhibitory strengths that collectively determine the suprathreshold tuning curves of cortical neurons. Long-term cortical plasticity also requires co-activation of subcortical neuromodulatory control nuclei such as the cholinergic nucleus basalis, particularly in adults. Regardless of developmental stage, regulation of inhibition seems to be a general mechanism by which changes in sensory experience and neuromodulatory state can remodel cortical receptive fields. We discuss recent findings suggesting that the microdynamics of synaptic receptive field plasticity unfold as a multi-phase set of distinct phenomena, initiated by disrupting the balance between excitation and inhibition, and eventually leading to wide-scale changes to many synapses throughout the cortex. These changes are coordinated to enhance the representations of newly-significant stimuli, possibly for improved signal processing and language learning in humans.
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DOI：
10.1523/jneurosci.4429-08.2008
发表时间：
2008-12-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dahmen JC;Hartley DE;King AJ
通讯作者：
King AJ
影响因子：
13.9
作者：
Feldman DE
通讯作者：
Feldman DE
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
34.7
作者：
Ascoli, Giorgio A.;Alonso-Nanclares, Lidia;Anderson, Stewart A.;Barrionuevo, German;Benavides-Piccione, Ruth;Burkhalter, Andreas;Buzsaki, Gyoergy;Cauli, Bruno;DeFelipe, Javier;Fairen, Alfonso;Feldmeyer, Dirk;Fishell, Gord;Fregnac, Yves;Freund, Tamas F.;Gardner, Daniel;Gardner, Esther P.;Goldberg, Jesse H.;Helmstaedter, Moritz;Hestrin, Shaul;Karube, Fuyuki;Kisvarday, Zoltan F.;Lambolez, Bertrand;Lewis, David A.;Marin, Oscar;Markram, Henry;Munoz, Alberto;Packer, Adam;Petersen, Carl C. H.;Rockland, Kathleen S.;Rossier, Jean;Rudy, Bernardo;Somogyi, Peter;Staiger, Jochen F.;Tamas, Gabor;Thomson, Alex M.;Toledo-Rodriguez, Maria;Wang, Yun;West, David C.;Yuste, Rafael
通讯作者：
Yuste, Rafael
影响因子：
16.2
作者：
Frenkel, MY;Bear, MF
通讯作者：
Bear, MF