Relationship between blood pressure and intraocular pressure in the JPHC-NEXT eye study.
Relationship between blood pressure and intraocular pressure in the JPHC-NEXT eye study.
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DOI：
10.1038/s41598-022-22301-1
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发表时间：
2022-10-19
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然高血压和眼内压（IOP）之间存在正相关，但收缩压和舒张压（分别为SBP和DBP）对IOP的个体影响仍不清楚，尤其是在日本人群中。在这里，我们进行了一项大规模的横断面研究，以确定SBP/DBP和高血压对IOP的单独和联合影响。总共有6783名40岁以上的日本人接受了全身和眼科检查，包括使用非接触式眼压计测量血压和IOP。在调整先验已知的混杂因素后，发现SBP和DBP水平与IOP水平呈正相关。当比较高血压组和正常血压组的高眼压患病率时，多变量校正的比值比为1.88（95%置信区间，1.14-3.08）。当分析SBP和DBP对高眼压的联合作用时，SBP升高对高眼压的影响大于DBP升高。总之，在眼科健康的日本人群中，SBP和DBP水平以及全身性高血压的患病率与IOP水平和高眼压的患病率呈正相关。我们的研究结果表明，全身血压控制可能是控制IOP的关键。
Although a positive link between hypertension and intraocular pressure (IOP) has been suggested, the individual effects of systolic and diastolic blood pressure (SBP and DBP, respectively) on IOP remain unclear, particularly among Japanese populations. Here, we conducted a large-scale, cross-sectional study to determine individual and combined effects of SBP/DBP and hypertension on IOP. In total, 6783 Japanese people aged over 40 years underwent systemic and ophthalmological examinations, including measurements of blood pressure and IOP, conducted using non-contact tonometers. After adjusting for a priori known confounding factors, SBP and DBP levels were found to be positively correlated with IOP levels. The multivariable-adjusted odds ratio when comparing the hypertensive and normotensive groups for the prevalence of ocular hypertension was 1.88 (95% confidence interval, 1.14–3.08). When analysing the combined effects of SBP and DBP on ocular hypertension, SBP elevation had a greater effect on ocular hypertension than DBP increase. In conclusion, SBP and DBP levels and the prevalence of systemic hypertension were found to be positively associated with IOP levels and the prevalence of ocular hypertension in an ophthalmologically healthy Japanese population. Our findings suggest that systemic blood pressure control may be key for controlling IOP.
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Memarzadeh, Farnaz;Ying-Lai, Me;Varma, Rohit
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Varma, Rohit
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Bhatt, Deepak L.
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