Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials.
Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials.
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DOI：
10.1038/ejcn.2016.78
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发表时间：
2016-11
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
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尽管绿茶被认为是有益的，但仍然存在与肝脏有关的安全问题，即摄入绿茶可能引起人类的肝毒性。尽管文献中已经报道了许多关于绿茶提取物的随机对照试验（rct），但迄今为止发表的系统评价仅基于对病例报告的主观评估。为了更客观地检查绿茶摄入与肝脏相关的安全性，我们对已发表的随机对照试验进行了系统回顾。2013年12月，我们使用PubMed、EMBASE和Cochrane Central Register of Controlled Trials三个数据库进行了系统的文献检索，以确定绿茶提取物的随机对照试验。肝脏相关不良事件的数据，包括实验室检查异常，从已识别的文章中摘录。评估随机对照试验的方法学质量。在排除重复后，筛选了561篇标题和摘要以及119篇全文文章，最终确定了34项试验。其中，4项试验报告了与肝脏相关的不良事件；这些不良事件涉及绿茶干预组的7名受试者（8次事件）和对照组的1名受试者（1次事件）。使用稀疏事件数据的荟萃分析方法估计，干预与安慰剂相比的总优势比为2.1（95%可信区间：0.5-9.8）。两组报告的少数事件都是肝酶升高。大多数是轻微的，没有严重的肝脏相关不良事件的报道。本综述的结果虽然不是结论性的，但表明摄入绿茶提取物后与肝脏相关的不良事件预计是罕见的。
There remain liver-related safety concerns, regarding potential hepatotoxicity in humans, induced by green tea intake, despite being supposedly beneficial. Although many randomized controlled trials (RCTs) of green tea extracts have been reported in the literature, the systematic reviews published to date were only based on subjective assessment of case reports. To more objectively examine the liver-related safety of green tea intake, we conducted a systematic review of published RCTs. A systematic literature search was conducted using three databases (PubMed, EMBASE and Cochrane Central Register of Controlled Trials) in December 2013 to identify RCTs of green tea extracts. Data on liver-related adverse events, including laboratory test abnormalities, were abstracted from the identified articles. Methodological quality of RCTs was assessed. After excluding duplicates, 561 titles and abstracts and 119 full-text articles were screened, and finally 34 trials were identified. Of these, liver-related adverse events were reported in four trials; these adverse events involved seven subjects (eight events) in the green tea intervention group and one subject (one event) in the control group. The summary odds ratio, estimated using a meta-analysis method for sparse event data, for intervention compared with placebo was 2.1 (95% confidence interval: 0.5–9.8). The few events reported in both groups were elevations of liver enzymes. Most were mild, and no serious liver-related adverse events were reported. Results of this review, although not conclusive, suggest that liver-related adverse events after intake of green tea extracts are expected to be rare.
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影响因子：
3.8
作者：
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通讯作者：
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DOI：
10.1097/00042737-200510000-00021
发表时间：
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DOI：
10.1080/07315724.2010.10719814
发表时间：
2010-02-01
影响因子：
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通讯作者：
Lyons, Timothy J.