Endocrine disrupting chemicals and disease susceptibility.
Endocrine disrupting chemicals and disease susceptibility.
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DOI：
10.1016/j.jsbmb.2011.08.007
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发表时间：
2011-11
影响因子：
4.1
通讯作者：
Heindel, Jerrold J.
中科院分区：
文献类型：
--
作者：
Schug, Thaddeus T.;Janesick, Amanda;Blumberg, Bruce;Heindel, Jerrold J.
关键词：
环境化学品对生物系统有重大影响。在发育的早期阶段暴露于化学品会破坏正常的发育模式，从而极大地改变生命后期的疾病易感性。内分泌干扰物（EDCs）干扰人体内分泌系统，对人体的发育、生殖、神经、心血管、代谢和免疫产生不利影响。许多天然和人造物质被认为会引起内分泌紊乱，包括药品、二恶英和二恶英类化合物、多氯联苯、滴滴涕和其他杀虫剂，以及双酚A（BPA）和邻苯二甲酸酯等塑料成分。内分泌干扰物存在于许多日常产品中，包括塑料瓶、金属食品罐、洗涤剂、阻燃剂、食品添加剂、玩具、化妆品和杀虫剂。内分泌干扰物干扰天然激素的合成、分泌、运输、活性或消除。这种干扰可以阻断或模仿激素的作用，引起广泛的影响。本文综述了内分泌干扰物改变激素信号的机制和作用方式。它还包括与内分泌干扰相关的选定疾病终点的简要概述。
Environmental chemicals have significant impacts on biological systems. Chemical exposures during early stages of development can disrupt normal patterns of development and thus dramatically alter disease susceptibility later in life. Endocrine disrupting chemicals (EDCs) interfere with the body's endocrine system and produce adverse developmental, reproductive, neurological, cardiovascular, metabolic and immune effects in humans. A wide range of substances, both natural and man-made, are thought to cause endocrine disruption, including pharmaceuticals, dioxin and dioxin-like compounds, polychlorinated biphenyls, DDT and other pesticides, and components of plastics such as bisphenol A (BPA) and phthalates. EDCs are found in many everyday products– including plastic bottles, metal food cans, detergents, flame retardants, food additives, toys, cosmetics, and pesticides. EDCs interfere with the synthesis, secretion, transport, activity, or elimination of natural hormones. This interference can block or mimic hormone action, causing a wide range of effects. This review focuses on the mechanisms and modes of action by which EDCs alter hormone signaling. It also includes brief overviews of select disease endpoints associated with endocrine disruption.
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发表时间：
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影响因子：
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作者：
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