Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni.
Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni.
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暴露史对曼氏血吸虫免疫学和耐药性发展的影响。
DOI：
10.1371/journal.pntd.0000637
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发表时间：
2010-03-23
影响因子：
3.8
通讯作者：
Colley DG
中科院分区：
文献类型：
--
作者：
Black CL;Mwinzi PN;Muok EM;Abudho B;Fitzsimmons CM;Dunne DW;Karanja DM;Secor WE;Colley DG
先前的研究表明，人类可以获得免疫力，以重新感染的寄生虫，最有可能是由于免疫机制后获得接触死亡寄生蠕虫。我们纵向跟踪两个队列的成年男性职业暴露于曼氏血吸虫清洗汽车（120人）或收获沙子（53人）在维多利亚湖。男性每次服用吡喹酮。发现曼氏感染。在洗车工中，通过测量在治愈和再感染之间清洗的汽车的数量，在洗车工平均经历了7次治愈之后，观察到对再感染的抵抗力显著增加。在产生耐药性的洗车工中，从基线到首次出现耐药性的时间，染色体特异性IgE水平增加。在沙收割机，一个显着增加的阻力，作为衡量治愈和再感染之间在湖中工作的天数，观察后，只有两个治愈。有S. mansoni在这两个群体之间是不同的，大多数的采沙者是一个村庄的终身居民，该村庄流行的S。mansoni和大多数洗车工在开始洗汽车之前几乎没有接触过湖水。研究开始时的免疫反应表明洗车工中的近期感染和采沙工中的慢性感染更多。抗再感染。成人在多次再感染和治愈后可获得或增强曼氏血吸虫，但通过这种方式获得耐药性的速度取决于免疫状态和暴露于曼氏血吸虫的历史。曼氏感染。血吸虫病是一种寄生性血吸虫感染，全世界有2亿人感染。我们已经证明，人类在反复接触吡喹酮药物并治愈后，可以获得对再感染的免疫力。对再感染抵抗力的增加与抗体特异性IgE的增加有关。在两个地理位置接近且职业暴露相似的人群中，产生耐药性的能力和获得耐药性的速度差异很大。这些差异可能归因于曼氏血吸虫感染史和基线免疫状态的差异，那些获得免疫力更快的人终身患有曼氏血吸虫病。mansoni暴露和慢性S.曼氏感染。由于在文献中报告了许多关于与对病毒感染产生耐药性相关的免疫学参数的相互矛盾的结果，因此在设计未来的免疫流行病学研究时应考虑暴露史和既往免疫状态。
Previous studies suggest that humans can acquire immunity to reinfection with schistosomes, most probably due to immunologic mechanisms acquired after exposure to dying schistosome worms. We followed longitudinally two cohorts of adult males occupationally exposed to Schistosoma mansoni by washing cars (120 men) or harvesting sand (53 men) in Lake Victoria. Men were treated with praziquantel each time S. mansoni infection was detected. In car washers, a significant increase in resistance to reinfection, as measured by the number of cars washed between cure and reinfection, was observed after the car washers had experienced, on average, seven cures. In the car washers who developed resistance, the level of schistosome-specific IgE increased between baseline and the time at which development of resistance was first evidenced. In the sand harvesters, a significant increase in resistance, as measured by the number of days worked in the lake between cure and reinfection, was observed after only two cures. History of exposure to S. mansoni differed between the two cohorts, with the majority of sand harvesters being lifelong residents of a village endemic for S. mansoni and the majority of car washers having little exposure to the lake before they began washing cars. Immune responses at study entry were indicative of more recent infections in car washers and more chronic infections in sand harvesters. Resistance to reinfection with S. mansoni can be acquired or augmented by adults after multiple rounds of reinfection and cure, but the rate at which resistance is acquired by this means depends on immunologic status and history of exposure to S. mansoni infection. Schistosomiasis is a parasitic blood fluke infection of 200 million people worldwide. We have shown that humans can acquire immunity to reinfection after repeated exposures and cures with the drug praziquantel. The increase in resistance to reinfection was associated with an increase in schistosome-specific IgE. The ability to develop resistance and the rate at which resistance was acquired varied greatly in two cohorts of men within close geographic proximity and with similar occupational exposures to schistosomes. These differences are likely attributable to differences in history of exposure to Schistosoma mansoni infection and immunologic status at baseline, with those acquiring immunity faster having lifelong S. mansoni exposure and immunologic evidence of chronic S. mansoni infection. As many conflicting results have been reported in the literature regarding immunologic parameters associated with the development of resistance to schistosome infection, exposure history and prior immune status should be considered in the design of future immuno-epidemiologic studies.
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DOI：
10.4269/ajtmh.1979.28.87
发表时间：
1979-01-01
影响因子：
3.3
作者：
LUNDE, MN;OTTESEN, EA;CHEEVER, AW
通讯作者：
CHEEVER, AW
影响因子：
6.4
作者：
Montenegro, SML;Miranda, P;Wynn, TA
通讯作者：
Wynn, TA
影响因子：
3.1
作者：
Naus, CWA;Kimani, G;Dunne, DW
通讯作者：
Dunne, DW
DOI：
10.4269/ajtmh.2000.62.57
发表时间：
2000-01-01
影响因子：
3.3
作者：
Caldas, IR;Correa-Oliveira, R;Gazzinelli, G
通讯作者：
Gazzinelli, G
影响因子：
3.1
作者：
Leenstra, T;Acosta, LP;Kurtis, JD
通讯作者：
Kurtis, JD