The nonlinear motion of cells subject to external forces.
The nonlinear motion of cells subject to external forces.
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作者：
为了开发细胞在拥挤环境（例如组织中）中移动的最小模型，我们研究了在平坦刚性基质上移动的活性物质液滴对其边界施加的力的响应。我们考虑了两种不同的自推进机制，主动应力和跑步聚合，并研究了这些表面力如何改变主动滴运动。我们发现对力的高度非线性响应，我们使用液滴速度、液滴形状以及液滴与基材之间的牵引力来表征。每个自推进机构都会产生两种主要的运动模式：在主体中具有零牵引力的细长下降，主要发生在强拉伸力下，以及在主体中具有有限牵引力的抛物线下降，主要在强挤压力下发生。在每种情况下，作为所施加的力的函数，在抛物线和细长的液滴之间存在急剧的过渡，并且在大的力拉伸液滴时存在液滴破裂的迹象。为了开发细胞在拥挤环境（例如组织中）中移动的最小模型，我们研究了在平坦刚性基质上移动的活性物质液滴对其边界施加的力的响应。
To develop a minimal model for a cell moving in a crowded environment such as in tissue, we investigate the response of a liquid drop of active matter moving on a flat rigid substrate to forces applied at its boundaries. We consider two different self-propulsion mechanisms, active stresses and treadmilling polymerisation, and we investigate how the active drop motion is altered by these surface forces. We find a highly non-linear response to forces that we characterise using drop velocity, drop shape, and the traction between the drop and the substrate. Each self-propulsion mechanism gives rise to two main modes of motion: a long thin drop with zero traction in the bulk, mostly occurring under strong stretching forces, and a parabolic drop with finite traction in the bulk, mostly occurring under strong squeezing forces. In each case there is a sharp transition between parabolic, and long thin drops as a function of the applied forces and indications of drop break-up where large forces stretch the drop. To develop a minimal model for a cell moving in a crowded environment such as in tissue, we investigate the response of a liquid drop of active matter moving on a flat rigid substrate to forces applied at its boundaries.
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DOI：
10.1103/physreve.95.012401
发表时间：
2017-01
期刊：
Physical review. E
影响因子：
--
作者：
Camley BA;Zhao Y;Li B;Levine H;Rappel WJ
通讯作者：
Rappel WJ
影响因子：
3.3
作者：
Leal-Egana, Aldo;Letort, Gaelle;Thery, Manuel
通讯作者：
Thery, Manuel
影响因子：
64.8
作者：
Keren, Kinneret;Pincus, Zachary;Theriot, Julie A.
通讯作者：
Theriot, Julie A.
影响因子：
7.5
作者：
Laemmermann, Tim;Sixt, Michael
通讯作者：
Sixt, Michael
影响因子：
64.8
作者：
通讯作者：
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