Polymer Additives to Personal Protective Equipment can Inactivate Pathogens.
Polymer Additives to Personal Protective Equipment can Inactivate Pathogens.
复制标题
DOI：
10.1007/s10439-022-03100-1
复制
发表时间：
2023-04
影响因子：
3.8
通讯作者：
von Recum, Horst A.
中科院分区：
文献类型：
--
作者：
Dogan, Alan B.;Dabkowski, Katherine E.;Cadnum, Jennifer L.;Donskey, Curtis J.;von Recum, Horst A.
关键词：
口罩已被证明是预防空气传播病原体的最好公共卫生工具。然而，在持续暴露的情况下，质量较低的“自己动手”口罩不能提供足够的保护，特别是在处理不当的情况下。此外，每天使用多个口罩会给个人防护装备(PPE)供应带来压力，而且在环境上是不可持续的。因此，临床和商业上都需要一种可重复使用的、可灭活病原体的口罩。在这里，我们建议在现有的织物网络中添加四元聚(二甲氨基十六烷基甲基丙烯酸酯)，Q(PDMAHDM)，缩写为Q(PDMAHDM)，以产生“接触杀死”口罩-有效地将棉、丙纶和聚酯转变为抗病原体材料。研究发现，Q(PDM)集成口罩对液体培养和雾化液滴中的革兰氏阳性菌和革兰氏阴性菌均有灭活作用。此外，Q(PDM)被电纺成均一的聚合物纤维，这使得该聚合物适用于低成本、放大生产。网上版载有补充材料，可在10.1007/s10439-022-03100-1查阅。
Face masks have been proven to be medicine’s best public health tool for preventing transmission of airborne pathogens. However, in situations with continuous exposure, lower quality and “do-it-yourself” face masks cannot provide adequate protection against pathogens, especially when mishandled. In addition, the use of multiple face masks each day places a strain on personal protective equipment (PPE) supply and is not environmentally sustainable. Therefore, there is a significant clinical and commercial need for a reusable, pathogen-inactivating face mask. Herein, we propose adding quaternary poly(dimethylaminohexadecyl methacrylate), q(PDMAHDM), abbreviated to q(PDM), to existing fabric networks to generate “contact-killing” face masks—effectively turning cotton, polypropylene, and polyester into pathogen resistant materials. It was found that q(PDM)-integrated face masks were able to inactivate both Gram-positive and Gram-negative bacteria in liquid culture and aerosolized droplets. Furthermore, q(PDM) was electrospun into homogeneous polymer fibers, which makes the polymer practical for low-cost, scaled-up production. The online version contains supplementary material available at 10.1007/s10439-022-03100-1.
登录
查看更多内容
影响因子：
--
作者：
Cadnum JL;Pearlmutter BS;Li DF;Jencson AL;Scott JG;Charnas IC;Donskey CJ
通讯作者：
Donskey CJ
影响因子：
5.5
作者：
Mann EE;Manna D;Mettetal MR;May RM;Dannemiller EM;Chung KK;Brennan AB;Reddy ST
通讯作者：
Reddy ST
影响因子：
3.4
作者：
Druvari, Denisa;Koromilas, Nikos D.;Kallitsis, Joannis K.
通讯作者：
Kallitsis, Joannis K.
影响因子：
11.8
作者：
MacIntyre CR;Cauchemez S;Dwyer DE;Seale H;Cheung P;Browne G;Fasher M;Wood J;Gao Z;Booy R;Ferguson N
通讯作者：
Ferguson N
影响因子：
4.6
作者：
Mai-Prochnow A;Clauson M;Hong J;Murphy AB
通讯作者：
Murphy AB