Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders.
Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders.
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DOI：
10.1016/j.cpnec.2022.100165
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发表时间：
2023-02
影响因子：
--
通讯作者：
Dell'Osso, Liliana
中科院分区：
文献类型：
--
作者：
Marazziti, Donatella;Carter, C. Sue;Carmassi, Claudia;Della Vecchia, Alessandra;Mucci, Federico;Pagni, Giovanni;Carbone, Manuel G.;Baroni, Stefano;Giannaccini, Gino;Palego, Lionella;Dell'Osso, Liliana
关键词：
催产素（OT）参与生理过程和情绪状态的调节，越来越多的证据表明其有益作用是由自主神经和免疫系统介导的。越来越多的证据表明，OT在不同的精神疾病的病理生理学中发挥作用。鉴于人类的信息有限，本研究的目的是回顾性地探讨精神病患者的血浆OT水平，特别是与健康对照组相比的性别相关差异。研究对象分为强迫症（OCD）、创伤后应激障碍（PTSD）和抑郁症（MDD）三组。健康男性和女性之间的血浆OT水平显着不同，后者显示更高的值，而没有三个精神病组显示与性别相关的参数在这里测量的差异。组间分析显示，强迫症患者的OT水平显著高于健康人，而PTSD患者的OT水平显著低于健康人，MDD患者的OT水平更显著低于健康人。当考虑性别时，这些差异也得到了证实，除了PTSD男性，他们的OT水平与健康男性相似。目前的研究结果表明，OT水平高于健康女性比男性，而性别差异不太明显或扭转精神病患者。心理病理学的性别差异减少可能与基本适应和社会功能相关过程中的差异脆弱性有关。催产素参与了几种精神疾病的病理生理学。在这项研究中，测量了精神病患者（即OCD，PTSD和MDD）的催产素血浆水平，并与健康对照组进行了比较。健康女性的催产素血浆水平高于男性。精神病患者的性别差异不明显或相反。
Oxytocin (OT) is involved in the regulation of physiological processes and emotional states, with increasing evidence for its beneficial actions being mediated by the autonomic and immune systems. Growing evidence suggests that OT plays a role in the pathophysiology of different psychiatric disorders. Given the limited information in humans the aim of this study was to retrospectively explore plasma OT levels in psychiatric patients, particularly focusing on sex-related differences, as compared with healthy controls. The patients studied here were divided into three groups diagnosed with obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD) or major depressive disorder (MDD). Plasma OT levels were significantly different between healthy men and women, with the latter showing higher values, while none of the three psychiatric groups showed sex-related differences in the parameters measured here. The intergroup analyses showed that the OT levels were significantly higher in OCD, lower in PTSD and even more reduced in MDD patients than in healthy subjects. These differences were also confirmed when gender was considered, with the exception of PTSD men, in whom OT levels were similar to those of healthy men. The present results indicated that OT levels were higher amongst healthy women than men, while a sex difference was less apparent or reversed in psychiatric patients. Reductions in sex differences in psychopathologies may be related to differential vulnerabilities in processes associated with basic adaptive and social functions. Oxytocin is involved in the pathophysiology of several psychiatric disorders. In this study oxytocin plasma levels were measured in psychiatric patients (i.e. OCD, PTSD and MDD) and compared to healthy controls. Oxytocin plasma levels were found were higher amongst healthy women than men. Gender difference was less apparent or reversed in psychiatric patients.
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