Nervous system regulation of the cancer genome.
Nervous system regulation of the cancer genome.
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DOI：
10.1016/j.bbi.2012.11.008
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Cole SW
中科院分区：
文献类型：
--
作者：
Cole SW
基于基因组学的分析为癌症的基础生物学提供了深刻的见解，现在正在澄清心理和社会因素可以调节肿瘤细胞基因表达和基因组进化的分子途径。本文综述了癌症基因组的神经和内分泌调节及其与周围肿瘤微环境的相互作用的基础和临床研究，包括受神经和内分泌调节的特定类型的基因，介导这种效应的信号转导途径，以及可能用于减轻其影响的治疗方法。已经发现来自交感神经系统的β-肾上腺素能信号传导上调多种基因，这些基因有助于肿瘤进展和转移，而糖皮质激素调节的基因可以抑制DNA修复并促进癌细胞存活和对化疗的抗性。社会环境风险因素、神经和内分泌信号传导至肿瘤微环境以及癌细胞和周围基质细胞的转录反应之间的关系为癌症的社会流行病学提供了新的机制见解，为保护癌症患者的健康提供了新的治疗方法，为评估行为和药理干预的影响提供了新的分子生物标志物。
Genomics-based analyses have provided deep insight into the basic biology of cancer and are now clarifying the molecular pathways by which psychological and social factors can regulate tumor cell gene expression and genome evolution. This review summarizes basic and clinical research on neural and endocrine regulation of the cancer genome and its interactions with the surrounding tumor microenvironment, including the specific types of genes subject to neural and endocrine regulation, the signal transduction pathways that mediate such effects, and therapeutic approaches that might be deployed to mitigate their impact. Beta-adrenergic signaling from the sympathetic nervous system has been found to up-regulated a diverse array of genes that contribute to tumor progression and metastasis, whereas glucocorticoid-regulated genes can inhibit DNA repair and promote cancer cell survival and resistance to chemotherapy. Relationships between socio-environmental risk factors, neural and endocrine signaling to the tumor microenvironment, and transcriptional responses by cancer cells and surrounding stromal cells are providing new mechanistic insights into the social epidemiology of cancer, new therapeutic approaches for protecting the health of cancer patients, and new molecular biomarkers for assessing the impact of behavioral and pharmacologic interventions.
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影响因子：
10.6
作者：
Antoni, Michael H.;Lutgendorf, Susan K.;Blomberg, Bonnie;Carver, Charles S.;Lechner, Suzanne;Diaz, Alain;Stagl, Jamie;Arevalo, Jesusa M. G.;Cole, Steven W.
通讯作者：
Cole, Steven W.
影响因子：
11
作者：
Chen, E.;Miller, G. E.;Kobor, M. S.;Cole, S. W.
通讯作者：
Cole, S. W.
DOI：
10.1126/science.1179050
发表时间：
2009-10-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Amit I;Garber M;Chevrier N;Leite AP;Donner Y;Eisenhaure T;Guttman M;Grenier JK;Li W;Zuk O;Schubert LA;Birditt B;Shay T;Goren A;Zhang X;Smith Z;Deering R;McDonald RC;Cabili M;Bernstein BE;Rinn JL;Meissner A;Root DE;Hacohen N;Regev A
通讯作者：
Regev A
影响因子：
45.3
作者：
Barron, Thomas I.;Connolly, Roisin M.;Visvanathan, Kala
通讯作者：
Visvanathan, Kala
影响因子：
15.1
作者：
Cole, Steve W.
通讯作者：
Cole, Steve W.