Temporal interference current stimulation in peripheral nerves is not driven by envelope extraction.
Temporal interference current stimulation in peripheral nerves is not driven by envelope extraction.
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颞叶干扰电流对周围神经的刺激不是由包络提取驱动的。
DOI：
10.1088/1741-2552/acc6f1
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发表时间：
2023-04-28
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
电神经调节仍然是一种有效的治疗多种神经系统疾病。电刺激神经的一种策略利用多个高频波形的干扰。这种技术，称为时间干扰刺激或干扰电流刺激，最近获得了显着的关注，作为一种方法，以提高最先进的神经刺激在动物研究和人体临床试验。在这里，我们报告我们的调查到这些类型的波形的神经元响应的基本特性-载波和包络频率的影响，阈值，发射行为，相位和不对称的干扰模式。我们利用大鼠坐骨神经上的袖状电极施加各种干扰信号。我们记录了足底肌肉和股二头肌的肌肉活动，它们是坐骨神经两个主要分支活动的代理，在目标体积中空间上是不同的。我们测试了基本的招募特性以及选择性激活任一肌肉群的空间技术。我们的数据表明，与目前接受的解释相反，神经元根本不提取包络，并且对这些信号的响应可以通过电阻-电容器（即，积分器）膜。基本的干扰技术不会改变远离电极的募集。这些技术可以产生阶段性激活和强直性激活/传导阻滞的区域。一个积分器模型表明，干扰技术是不太能够微创刺激皮层下的大脑目标比以前认为的。使用这些技术的人体临床试验应该重新评估他们的方法。干扰刺激允许在目标靠近电极的外周袖带电极中具有显著的目标选择性。这些技术可以允许空间上不同的相位放电、强直放电、传导阻滞和无效应区域。
Electrical neuromodulation remains an effective therapy for multiple neurological disorders. One strategy to electrically stimulate nerves utilizes the interference of multiple high frequency waveforms. This technique, known as temporal interference stimulation or interferential current stimulation, has recently gained significant attention as a method to improve the state-of-the-art in neurostimulation in both animal studies and human clinical trials. Here we report our investigation into the fundamental properties of the neuronal response to these types of waveforms – the effects of carrier and envelope frequencies, thresholds, firing behavior, and phase and asymmetric interference patterns. We utilized a cuff electrode on the rat sciatic nerve to apply a variety of interferential signals. We recorded muscle activity in the plantar muscles and biceps femoris, which are proxies for activity on two of the major branches of the sciatic, which are spatially distinct in the target volume. We tested both fundamental recruitment properties as well as spatial techniques to selectively activate either muscle group. Our data suggest, contrary to the currently accepted explanation, that neurons do not extract envelopes at all, and that the response to these signals is well explained by a resistor-capacitor (i.e., integrator) membrane with a fixed firing threshold. Basic interference techniques do not change recruitment far from electrodes. Techniques can produce regions of both phasic activation and tonic activation / conduction block. An integrator model suggests that interference techniques are less capable of minimally invasive stimulation for a subcortical brain target than previously thought. Human clinical trials using these techniques should reevaluate their methods. Interference stimulation allows significant target selectivity in a peripheral cuff electrode with targets near electrodes. These techniques can allow spatially distinct regions of phasic firing, tonic firing, conduction block, and no effect.
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影响因子：
3
作者：
Franke, Manfred;Bhadra, Niloy;Bhadra, Narendra;Kilgore, Kevin
通讯作者：
Kilgore, Kevin
缺血性中风中的迷走神经刺激：新瓶中的旧酒。
影响因子：
3.4
作者：
Cai PY;Bodhit A;Derequito R;Ansari S;Abukhalil F;Thenkabail S;Ganji S;Saravanapavan P;Shekar CC;Bidari S;Waters MF;Hedna VS
通讯作者：
Hedna VS
影响因子：
3.2
作者：
Pelot NA;Thio BJ;Grill WM
通讯作者：
Grill WM
DOI：
10.1109/tnsre.2015.2421732
发表时间：
2015-11-01
影响因子：
4.9
作者：
Qing, Kurt Y.;Ward, Matthew P.;Irazoqui, Pedro P.
通讯作者：
Irazoqui, Pedro P.
影响因子：
4.6
作者：
Cao, Jiaming;Grover, Pulkit
通讯作者：
Grover, Pulkit