Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study.
Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study.
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DOI：
10.1186/1471-2458-13-862
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发表时间：
2013-09-18
影响因子：
4.5
通讯作者：
Kiyohara Y
中科院分区：
文献类型：
--
作者：
Sekita A;Arima H;Ninomiya T;Ohara T;Doi Y;Hirakawa Y;Fukuhara M;Hata J;Yonemoto K;Ga Y;Kitazono T;Kanba S;Kiyohara Y
代谢综合征（MetS）和抑郁症之间的联系仍然不确定。我们的目的是评估代谢综合征和抑郁症状升高之间的关联在一般日本人群。这是一项对3，113名40岁或40岁以上的社区居民进行的横断面调查。MetS是根据联合临时声明定义的。当受试者具有以下组分中的三种或更多种时，诊断为MetS：（男性腰围≥90 cm，女性腰围≥80 cm）; 2）血压升高（≥130/85 mmHg或目前使用降压药物）; 3）高血压血症（≥1.7 mmol/L）; 4）低HDL胆固醇（男性< 1.0 mmol/L，女性< 1.3 mmol/L）;和5）空腹血糖升高（≥5.55 mmol/L或目前使用抗糖尿病药物）。采用流行病学研究中心抑郁量表（CES-D）评估抑郁症状。使用逻辑回归模型估计年龄和多变量调整的比值比（OR）和95%置信区间（CI）。在4.3%的男性和6.3%的女性参与者中观察到抑郁症状升高。在男性中，代谢综合征受试者中抑郁症状升高的年龄调整患病率显著高于无代谢综合征受试者（7.1% vs 3.6%，p = 0.04）。随着MetS组分数量的增加，抑郁症状升高的患病率逐渐升高（0-1、2、3和≥4个组分的男性受试者分别为3.5%、3.6%、5.8%和9.2%;趋势p = 0.02）。即使在调整了年龄、婚姻状况、心血管疾病史、吸烟习惯、饮酒和定期锻炼等因素后，这种相关性仍然显著。另一方面，在女性中，MetS和抑郁症状之间没有明确的联系。MetS与日本男性一般人群中抑郁症状的升高相关。
Uncertainty still surrounds the association between metabolic syndrome (MetS) and depression. We aimed to evaluate the association between MetS and elevated depressive symptoms in a general Japanese population. This is a cross-sectional survey of 3,113 community-dwelling individuals aged 40 years or over. MetS was defined according to the joint interim statement. MetS was diagnosed when a subject had three or more of the following components: 1) central obesity (waist circumference ≥90 cm for men, ≥80 cm in for women); 2) elevated blood pressure (≥130/85 mmHg or current use of antihypertensive medication); 3) hypertriglyceridemia (≥1.7 mmol/L); 4) low HDL cholesterol (< 1.0 mmol/L for men, < 1.3 mmol/L for women); and 5) elevated fasting plasma glucose (≥5.55 mmol/L or current use of antidiabetic medication). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). The age- and multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using a logistic regression model. Elevated depressive symptoms were observed in 4.3% of male and 6.3% of female participants. In men, the age-adjusted prevalence of elevated depressive symptoms was significantly higher in subjects with MetS than in those without (7.1% versus 3.6%, p = 0.04). The prevalence of elevated depressive symptoms rose progressively as the number of MetS components increased (3.5%, 3.6%, 5.8%, and 9.2% in male subjects with 0–1, 2, 3, and ≥4 components, respectively; p = 0.02 for trend). This association remained significant even after adjustment for age, marital status, history of cardiovascular disease, smoking habit, alcohol intake, and regular exercise. In women, on the other hand, there was no clear association between MetS and depressive symptoms. MetS was associated with elevated depressive symptoms in a general population of Japanese men.
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影响因子：
16.2
作者：
Akbaraly TN;Ancelin ML;Jaussent I;Ritchie C;Barberger-Gateau P;Dufouil C;Kivimaki M;Berr C;Ritchie K
通讯作者：
Ritchie K
肥胖和代谢综合征会增加老年男性患抑郁症的风险：男性健康研究
影响因子：
7.2
作者：
Almeida, Osvaldo P.;Calver, Janine;Flicker, Leon
通讯作者：
Flicker, Leon
影响因子：
8.3
作者：
Santos, Micaela;Gold, Gabriel;Giannakopoulos, Panteleimon
通讯作者：
Giannakopoulos, Panteleimon
影响因子：
2.1
作者：
East, Cara;Willis, Benjamin L.;Trivedi, Madhukar H.
通讯作者：
Trivedi, Madhukar H.
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.