C-H bond functionalization via hydride transfer: direct coupling of unactivated alkynes and sp(3) C-H bonds catalyzed by platinum tetraiodide.
C-H bond functionalization via hydride transfer: direct coupling of unactivated alkynes and sp(3) C-H bonds catalyzed by platinum tetraiodide.
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DOI：
10.1021/ja906480w
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发表时间：
2009-11-18
影响因子：
15
通讯作者：
Sames, Dalibor
中科院分区：
文献类型：
--
作者：
Vadola, Paul A.;Sames, Dalibor
We report a catalytic intramolecular coupling between terminal unactivated alkynes and sp3 C-H bonds via the through-space hydride transfer (HT-cyclization of alkynes). This method enables one-step preparation of complex heterocyclic compounds by α-alkenylation of readily available cyclic ethers and amines. We show that PtI4 is an effective Lewis acid catalyst for the activation of terminal alkynes for the hydride attack and subsequent C-C bond formation. In addition, we have shown that the activity of neutral platinum salts (PtXn) can be modulated by the halide ligands. This modulation in turn allows for fine-tuning of the platinum center reactivity to match the reactivity and stability of selected substrates and products.
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影响因子：
5.2
作者：
Pastine, SJ;Youn, SW;Sames, D
通讯作者：
Sames, D
影响因子：
5.2
作者：
Pastine, SJ;Sames, D
通讯作者：
Sames, D
影响因子：
3.6
作者：
Odedra, Arjan;Datta, Swarup;Liu, Rai-Shung
通讯作者：
Liu, Rai-Shung
影响因子：
5.2
作者：
Pastine, SJ;Sames, D
通讯作者：
Sames, D
影响因子：
15
作者：
Pastine, SJ;McQuaid, KM;Sames, D
通讯作者：
Sames, D