Quantitative 3.0T MR spectroscopy reveals decreased creatine concentration in the dorsolateral prefrontal cortex of patients with social anxiety disorder.
Quantitative 3.0T MR spectroscopy reveals decreased creatine concentration in the dorsolateral prefrontal cortex of patients with social anxiety disorder.
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定量 3.0T 磁共振波谱显示社交焦虑症患者背外侧前额皮质肌酸浓度降低
DOI：
10.1371/journal.pone.0048105
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Gong Q
中科院分区：
文献类型：
--
作者：
Yue Q;Liu M;Nie X;Wu Q;Li J;Zhang W;Huang X;Gong Q
背景：社交焦虑的脑生化变化尚不清楚，尽管已有少量利用代谢物/肌酸比值的磁共振波谱研究。本研究旨在应用定量磁共振波谱技术探讨社交焦虑障碍患者绝对代谢产物浓度的变化。材料与方法使用3.0T磁共振扫描仪，对9例无药物治疗的社交焦虑症患者和9例正常对照的左侧前额叶背外侧皮质及相关区域进行单体素磁共振波谱分析(刺激回声采集模式，TR/TE/TM = 2 0 0/2 0/16ms)。以组织水为内参照计算绝对代谢物浓度，并对脑脊液的部分体积进行校正。结果患者左侧前额叶背外侧皮质N-乙酰天冬氨酸/肌酸比值明显高于对照组，其原因是肌酸浓度降低，而不是N-乙酰天冬氨酸浓度升高。此外，左侧背外侧前额叶皮质肌酸浓度与Liebowitz社交焦虑量表评分呈负相关。结论社交焦虑障碍患者左侧背外侧前额叶皮质肌酸水平的改变提示能量代谢异常，并与症状严重程度相关。而代谢物浓度比代谢物/肌酸比值更适合于研究社交焦虑障碍个体绝对代谢物的变化。
Background The brain biochemical changes of social anxiety have not been clarified although there have been a limited number of MR spectroscopic studies which utilized metabolite/creatine ratios. Present study aimed to explore the alteration of absolute metabolite concentration in social anxiety disorder using quantitative MR spectroscopy. Materials and Methods With a 3.0T MR scanner, single voxel MR spectroscopy (stimulated echo acquisition mode, TR/TE/TM = 2000/20/16 ms) was performed in the left dorsolateral prefrontal cortex and related regions of nine medication-free patients with social anxiety disorder and nine controls. Absolute metabolite concentration was calculated using tissue water as the internal reference and corrected for the partial volume of cerebrospinal fluid. Results In the left dorsolateral prefrontal cortex, the N-acetyl aspartate/creatine ratio of patients was significantly higher than that of controls, and this was due to the decrease of creatine concentration instead of the increase of N-acetyl aspartate concentration. Furthermore, the creatine concentration of the left dorsolateral prefrontal cortex was negatively correlated with the scores of Liebowitz social anxiety scale. Conclusions The alteration of creatine level in the left dorsolateral prefrontal cortex suggests abnormal energy metabolism and correlates with symptom severity in social anxiety disorder. And metabolite concentration is preferable to metabolite/creatine ratio for the investigation of individual, absolute metabolite changes in this region of social anxiety disorder.
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影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
2.5
作者：
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通讯作者：
Soares, JC
影响因子：
7.4
作者：
Gemar, Michael C.;Segal, Zindel V.;Carney, Colleen
通讯作者：
Carney, Colleen
影响因子：
2.5
作者：
Helms, G
通讯作者：
Helms, G
影响因子：
16.2
作者：
Delgado MR;Nearing KI;Ledoux JE;Phelps EA
通讯作者：
Phelps EA