Rapid vacuum sintering: A novel technique for fabricating fluorapatite ceramic scaffolds for bone tissue engineering.
Rapid vacuum sintering: A novel technique for fabricating fluorapatite ceramic scaffolds for bone tissue engineering.
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DOI：
10.1002/jbm.b.33825
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Holloway JA
中科院分区：
文献类型：
--
作者：
Denry I;Goudouri OM;Harless J;Holloway JA
大孔生物陶瓷支架通常通过泡沫复制技术制造，基于用玻璃浆液浸渍聚合物泡沫，然后缓慢热处理以允许干燥，聚合物烧坏和玻璃颗粒烧结。因此，由于玻璃同时结晶，这一过程既耗时又复杂，常常导致烧结不完全。我们的目的是研究加热速率对氟磷灰石基玻璃和玻璃陶瓷支架的烧结行为、结构和力学性能的影响。采用快速真空烧结（RVS）法制备玻璃支架，温度为785℃，真空条件下快速升温（55℃/min）或不真空，缓慢升温（2℃/min）。另外两组在775℃/1h下进一步结晶。XRD证实了结晶支架中氟磷灰石的存在。所有组的孔隙度均在500 μm范围内。RVS法制备的支架具有良好的烧结程度，而慢烧法制备的支架烧结不完全。RVS组的平均抗压强度（1.52±0.55和1.72±0.61 MPa）明显高于慢烧组（0.54±0.30和0.45±0.26 MPa）。同时，使用RVS技术，总生产时间减少了12小时以上。
Macroporous bioceramic scaffolds are often fabricated via the foam replica technique, based on polymeric foam impregnation with a glass slurry, followed by slow heat treatment to allow for drying, polymeric burnout, and sintering of the glass particles. As a consequence, the process is time consuming and complicated by concurrent crystallization of the glass, often leading to incomplete sintering. Our goal was to investigate the effect of heating rate on sintering behavior, architecture and mechanical properties of fluorapatite-based glass and glass-ceramic scaffolds. Glass scaffolds were prepared and sintered by rapid vacuum sintering (RVS) at 785ºC under vacuum at a fast heating rate (55ºC/min.) or without vacuum at a slow heating rate (2ºC/min.). Two additional groups were further crystallized at 775ºC/1h. XRD confirmed the presence of fluorapatite for crystallized scaffolds. All groups presented interconnected porosity with a pore size in the 500 μm range. Scaffolds produced by RVS exhibited an excellent degree of sintering while scaffolds produced by slow sintering were incompletely sintered. The mean compressive strength was significantly higher for the RVS groups (1.52 ± 0.55 and 1.72 ± 0.61 MPa) compared to the slow-sintered groups (0.54 ± 0.30 and 0.45 ± 0.26 MPa). Meanwhile, the total production time was reduced by more than 12 hours by using the RVS technique.
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影响因子：
3.5
作者：
Brauer, D. S.;Anjum, M. N.;Hill, R. G.
通讯作者：
Hill, R. G.
DOI：
10.1016/j.msec.2009.04.002
发表时间：
2009-08-01
影响因子：
7.9
作者：
Baino, Francesco;Verne, Enrica;Vitale-Brovarone, Chiara
通讯作者：
Vitale-Brovarone, Chiara
影响因子：
14
作者：
Chen, QZZ;Thompson, ID;Boccaccini, AR
通讯作者：
Boccaccini, AR
影响因子：
5.2
作者：
Bogdanov, B. I.;Pashev, P. S.;Markovska, I. G.
通讯作者：
Markovska, I. G.
DOI：
10.1016/j.jeurceramsoc.2016.01.011
发表时间：
2016-08-01
影响因子：
5.7
作者：
Baino, Francesco;Caddeo, Silvia;Vitale-Brovarone, Chiara
通讯作者：
Vitale-Brovarone, Chiara