Fish oil regulates blood fatty acid composition and oxylipin levels in healthy humans: A comparison of young and older men.
Fish oil regulates blood fatty acid composition and oxylipin levels in healthy humans: A comparison of young and older men.
复制标题
鱼油调节健康人的血液脂肪酸组成和氧脂质水平：年轻和老年男性的比较。
DOI：
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复制
发表时间：
2016
影响因子：
5.2
通讯作者：
D. Mutch
中科院分区：
文献类型：
--
作者：
M. Zulyniak;K. Roke;C. Gerling;Samantha Logan;L. Spriet;D. Mutch
范围
增加食用富含二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的鱼油与改善心脏代谢健康和炎症状态有关；然而，与年龄相关的反应仍然缺乏描述。
方法和结果
在一项安慰剂对照研究中，健康的年轻和老年男性每天服用 5 粒鱼油胶囊，提供 2.0 克/天的 EPA 和 1.0 克/天的 DHA，持续三个月。补充鱼油后，年轻和老年男性的血液甘油三酯均降低了约 30%。观察到 DHA 存在显着的组×时间交互作用，年轻男性血清和红细胞中的 DHA 增加了一倍，而老年男性的增加可以忽略不计。其他脂肪酸在年轻男性和老年男性之间的调节存在差异，最显着的是奥斯邦德酸和几种饱和脂肪酸。血清氧脂质发生了微小变化，两组男性的反应相似：5-HETE 减少，而 PGF2α 和 17-HDoHE 增加。氧脂素的变化与调节氧脂素产生的关键基因的全血表达的变化无关。
结论
我们的研究表明，年轻和老年男性都体验到与鱼油补充剂相关的降低甘油三酯的益处，但在血液脂肪酸方面表现出不同的反应。此外，鱼油还能改善两组男性的氧脂质水平。
SCOPE
Increased consumption of fish oils rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is associated with improved cardiometabolic health and inflammatory status; however, age-related responses remain poorly described.
METHODS AND RESULTS
In a placebo-controlled study, healthy young and older men consumed five fish oil capsules daily, providing 2.0 g/d EPA and 1.0g/d DHA, for three months. Both young and older men experienced a ∼30% reduction in blood triglycerides with fish oil supplementation. A significant group × time interaction was observed for DHA, with young men experiencing a ∼twofold increase in DHA in serum and RBCs, while older men showed negligible increases. Other fatty acids were differentially regulated between young and older men, most notably osbond acid and several saturates. Small changes were observed in serum oxylipins, with both groups of men responding similarly: 5-HETE was reduced, while PGF2α and 17-HDoHE were increased. Changes in oxylipins occurred independent of changes in whole blood expression of key genes regulating oxylipin production.
CONCLUSION
Our study suggests that both young and older men experience the triglyceride-lowering benefits associated with fish oil supplements, but show differential responses in blood fatty acids. Additionally, fish oil promotes an improved oxylipin profile in both groups of men.
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影响因子：
4.2
作者：
MEYDANI, SN;ENDRES, S;GORBACH, SL
通讯作者：
GORBACH, SL
影响因子：
62.1
作者：
Serhan, Charles N.;Petasis, Nicos A.
通讯作者：
Petasis, Nicos A.
影响因子：
7.1
作者：
Lemaitre, Rozenn N.;Fretts, Amanda M.;Mozaffarian, Dariush
通讯作者：
Mozaffarian, Dariush
DOI：
10.1016/j.bbalip.2014.10.008
发表时间：
2015-04
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Powell WS;Rokach J
通讯作者：
Rokach J
DOI：
10.1016/j.plefa.2013.04.001
发表时间：
2013-07
影响因子：
3
作者：
Schuchardt, Jan Philipp;Schmidt, Simone;Kressel, Gaby;Dong, Hua;Willenberg, Ina;Hammock, Bruce D.;Hahn, Andreas;Schebb, Nils Helge
通讯作者：
Schebb, Nils Helge