(18)F-Sodium Fluoride PET as a Diagnostic Modality for Metabolic, Autoimmune, and Osteogenic Bone Disorders: Cellular Mechanisms and Clinical Applications.
(18)F-Sodium Fluoride PET as a Diagnostic Modality for Metabolic, Autoimmune, and Osteogenic Bone Disorders: Cellular Mechanisms and Clinical Applications.
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DOI：
10.3390/ijms22126504
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发表时间：
2021-06-17
影响因子：
5.6
通讯作者：
Alavi A
中科院分区：
文献类型：
--
作者：
Park PSU;Raynor WY;Sun Y;Werner TJ;Rajapakse CS;Alavi A
在一个健康的身体中，破骨细胞和成骨细胞的稳态作用维持了骨骼系统的完整性。当破骨细胞和成骨细胞的细胞活动异常时，就会发生骨病理，如骨质疏松症。传统的成像方式，如x线摄影，对总体病理发现之前的早期细胞变化不敏感，经常导致疾病诊断延迟和治疗策略不理想。18f -氟化钠(18F-NaF)-正电子发射断层扫描（PET）是一种新兴的成像方式，通过检测细微的代谢变化，具有早期诊断和监测骨骼疾病的潜力。具体来说，游离的18F-被纳入羟基磷灰石中，其摄取反映成骨细胞活性和骨灌注，从而可以量化骨转换。虽然18F-NaF-PET传统上用于检测转移性骨病，但最近的文献证实了18F-NaF-PET在良性骨病中的应用。在这篇综述中，我们讨论了18f - naff - pet的细胞机制，并研究了其在多种代谢、自身免疫性和成骨性骨疾病中的临床应用的最新发现。
In a healthy body, homeostatic actions of osteoclasts and osteoblasts maintain the integrity of the skeletal system. When cellular activities of osteoclasts and osteoblasts become abnormal, pathological bone conditions, such as osteoporosis, can occur. Traditional imaging modalities, such as radiographs, are insensitive to the early cellular changes that precede gross pathological findings, often leading to delayed disease diagnoses and suboptimal therapeutic strategies. 18F-sodium fluoride (18F-NaF)-positron emission tomography (PET) is an emerging imaging modality with the potential for early diagnosis and monitoring of bone diseases through the detection of subtle metabolic changes. Specifically, the dissociated 18F- is incorporated into hydroxyapatite, and its uptake reflects osteoblastic activity and bone perfusion, allowing for the quantification of bone turnover. While 18F-NaF-PET has traditionally been used to detect metastatic bone disease, recent literature corroborates the use of 18F-NaF-PET in benign osseous conditions as well. In this review, we discuss the cellular mechanisms of 18F-NaF-PET and examine recent findings on its clinical application in diverse metabolic, autoimmune, and osteogenic bone disorders.
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影响因子：
2.8
作者：
Berardi S;Corrado A;Maruotti N;Cici D;Cantatore FP
通讯作者：
Cantatore FP
[（18）F] FDG和钠[（18）F]氟化物PET评估骨肉瘤异种移植模型中代谢模式和新的抗肿瘤治疗。
影响因子：
3.8
作者：
Collantes M;Martínez-Vélez N;Zalacain M;Marrodán L;Ecay M;García-Velloso MJ;Alonso MM;Patiño-García A;Peñuelas I
通讯作者：
Peñuelas I
影响因子：
4.1
作者：
Botman, Esmee;Raijmakers, Pieter G. H. M.;Eekhoff, E. Marelise W.
通讯作者：
Eekhoff, E. Marelise W.
影响因子：
4.3
作者：
Baum, Rebecca;Gravallese, Ellen M.
通讯作者：
Gravallese, Ellen M.
影响因子：
6
作者：
Amarasekara DS;Yun H;Kim S;Lee N;Kim H;Rho J
通讯作者：
Rho J