Neural stimulation and recording performance in human sensorimotor cortex over 1500 days.
Neural stimulation and recording performance in human sensorimotor cortex over 1500 days.
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DOI：
10.1088/1741-2552/ac18ad
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发表时间：
2021-08-13
影响因子：
4
通讯作者：
Gaunt RA
中科院分区：
文献类型：
--
作者：
Hughes CL;Flesher SN;Weiss JM;Downey JE;Boninger M;Collinger JL;Gaunt RA
体感皮层皮质内微刺激 (ICMS) 可以恢复脊髓损伤或其他疾病患者的感觉。慢性 ICMS 的一个潜在挑战是神经记录和刺激能否在多年内保持稳定。这是特别相关的，因为植入微电极阵列的记录质量会随着时间的推移而降低，并且刺激寿命的限制被认为是 ICMS 临床使用的潜在障碍。我们的目的是评估人类参与者在长期植入期间体感和运动皮层皮质内刺激溅射氧化铱 (SIROF) 和非刺激铂电极的记录稳定性。此外，我们还测量了 ICMS 如何随着时间的推移唤起感觉。在一项研究双向脑机接口皮质内植入物的研究中，我们将带有 SIROF 尖端的微电极阵列植入患有颈髓损伤的人类参与者的体感皮层中。我们定期刺激这些电极以唤起手上的触觉。在这里，我们通过两种方式量化这些电极与植入运动皮层的非刺激铂电极在 1500 天内的稳定性：记录的信号质量和电极阻抗。此外，我们使用检测阈值量化 ICMS 诱发的感觉的感知稳定性。我们发现，受激 SIROF 和非受激铂电极的记录质量（通过高振幅波形（> 100 μV 峰峰值）、峰峰值电压、噪声和信噪比的电极数量来评估）通常会随着时间的推移而下降。然而，受刺激的 SIROF 电极比未受刺激的铂电极更有可能继续记录高振幅信号。有趣的是，刺激引起的触觉的检测阈值随着时间的推移从第 100 天的中位数 31.5 μA 下降到第 1500 天的 10.4 μA，其中最显着的变化发生在第 100 天和第 500 天之间。这些结果证明，人类体感皮层中的 ICMS 可以在很长一段时间内提供，而不会对记录或刺激能力产生有害影响。事实上，随着时间的推移，对刺激的敏感性有所提高。
Intracortical microstimulation (ICMS) in somatosensory cortex can restore sensation to people with spinal cord injury or other conditions. One potential challenge for chronic ICMS is whether neural recording and stimulation can remain stable over many years. This is particularly relevant since the recording quality from implanted microelectrode arrays can degrade over time and limitations in stimulation longevity have been considered a potential barrier to the clinical use of ICMS. Our objective was to evaluate recording stability on intracortical stimulated sputtered iridium oxide (SIROF) and non-stimulated platinum electrodes in somatosensory and motor cortex in a human participant across a long period of implantation. Additionally, we measured how ICMS was able to evoke sensations over time. In a study investigating intracortical implants for a bidirectional brain-computer interface, we implanted microelectrode arrays with SIROF tips in the somatosensory cortex of a human participant with a cervical spinal cord injury. We regularly stimulated these electrodes to evoke tactile sensations on the hand. Here, we quantify the stability of these electrodes in comparison to non-stimulated platinum electrodes implanted in the motor cortex over 1500 days in two ways: recorded signal quality and electrode impedances. Additionally, we quantify the perceptual stability of ICMS-evoked sensations using detection thresholds. We found that recording quality, as assessed by the number of electrodes with high-amplitude waveforms (> 100 μV peak-to-peak), peak-to-peak voltage, noise, and signal-to-noise ratio, generally decreased over time on stimulated SIROF and non-stimulated platinum electrodes. However, stimulated SIROF electrodes were much more likely to continue to record high-amplitude signals than non-stimulated platinum electrodes. Interestingly, the detection thresholds for stimulus-evoked tactile sensations decreased over time from a median of 31.5 μA at day 100 to 10.4 μA at day 1500, with the most substantial changes occurring between day 100 and 500. These results provide evidence that ICMS in human somatosensory cortex can be provided over long periods of time without deleterious effects on recording or stimulation capabilities. In fact, the sensitivity to stimulation improved over time.
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影响因子：
4
作者：
Chestek CA;Gilja V;Nuyujukian P;Foster JD;Fan JM;Kaufman MT;Churchland MM;Rivera-Alvidrez Z;Cunningham JP;Ryu SI;Shenoy KV
通讯作者：
Shenoy KV
影响因子：
3
作者：
Negi S;Bhandari R;Rieth L;Van Wagenen R;Solzbacher F
通讯作者：
Solzbacher F
影响因子：
5.3
作者：
AGNEW, WF;YUEN, TGH;BULLARA, LA
通讯作者：
BULLARA, LA
影响因子：
4
作者：
McCreery D;Pikov V;Troyk PR
通讯作者：
Troyk PR
影响因子：
4
作者：
Callier, Thierri;Schluter, Erik W.;Bensmaia, Sliman J.
通讯作者：
Bensmaia, Sliman J.