Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light.
Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light.
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DOI：
10.3389/fphys.2022.934591
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发表时间：
2022
影响因子：
4
通讯作者：
Buhr, Ethan D.
中科院分区：
文献类型：
--
作者：
Diaz, Nicolas M.;Gordon, Shannon A.;Lang, Richard A.;Buhr, Ethan D.
哺乳动物将其体内温度保持在生理上的最佳范围内。这涉及到对核心体温的调节，以应对环境温度的变化和内部温度的自然昼夜振荡。下丘脑的视前区(POA)通过对外部温度信号和大脑内部温度做出反应来协调体温。在这里，我们描述了在小鼠腹内侧角(VMPO)中的一个自主昼夜节律时钟系统，该系统靠近表达非典型紫光敏感视蛋白OPN5的细胞。我们分析了体外培养的VMPO生物钟的光敏和热敏特性。VMPO昼夜振荡的相位不受光的影响。然而，VMPO时钟在生理内部温度范围内通过温度变化而被重置。VMPO昼夜节律时钟的这种温度敏感性不需要OPN5的功能表达或表达OPN5的细胞内的功能昼夜时钟。VMPO中对温度敏感的昼夜节律时钟的存在促进了对核心体温动态调节机制的理解。
Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperatures. The preoptic area (POA) of the hypothalamus coordinates body temperature by responding to both external temperature cues and internal brain temperature. Here we describe an autonomous circadian clock system in the murine ventromedial POA (VMPO) in close proximity to cells which express the atypical violet-light sensitive opsin, Opn5. We analyzed the light-sensitivity and thermal-sensitivity of the VMPO circadian clocks ex vivo. The phase of the VMPO circadian oscillations was not influenced by light. However, the VMPO clocks were reset by temperature changes within the physiological internal temperature range. This thermal-sensitivity of the VMPO circadian clock did not require functional Opn5 expression or a functional circadian clock within the Opn5-expressing cells. The presence of temperature-sensitive circadian clocks in the VMPO provides an advancement in the understanding of mechanisms involved in the dynamic regulation of core body temperature.
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影响因子：
4.6
作者：
Pérez-Cerezales S;Boryshpolets S;Afanzar O;Brandis A;Nevo R;Kiss V;Eisenbach M
通讯作者：
Eisenbach M
影响因子：
3.4
作者：
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通讯作者：
Herzog, ED
DOI：
10.1073/pnas.1006393107
发表时间：
2010-08-24
影响因子：
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作者：
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通讯作者：
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影响因子：
5.5
作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
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