Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson's disease.
Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson's disease.
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DOI：
10.1038/s41531-021-00158-x
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发表时间：
2021-02-15
期刊：
影响因子：
--
通讯作者：
Narayanan NS
中科院分区：
文献类型：
--
作者：
Singh A;Cole RC;Espinoza AI;Evans A;Cao S;Cavanagh JF;Narayanan NS
帕金森病（PD）患者可能有明显的认知功能障碍；然而，这些认知症状的机制尚不清楚。在这里，我们使用头皮脑电图（EEG）来研究间隔时间期间pd相关认知障碍的皮质基础，这需要参与者估计几秒钟的时间间隔。时间估计是研究帕金森病认知的理想任务需求，因为它简单，需要内侧额叶皮质区，并且需要基本的执行过程，如工作记忆和注意力。然而，间隔时间从未系统地研究PD患者的认知障碍。我们报告了三个主要发现。首先，与37名人口统计学匹配的对照组相比，71名PD患者的时间变异性增加，这种变异性与蒙特利尔认知评估（MOCA）测量的认知功能障碍相关。其次，PD患者前额正中电极的脑电振荡活动在间隔性提示下减弱~ 4hz，这也预示着MOCA的发生。最后，逐次线性混合效应模型表明，线索触发的~4 Hz功率作为PD和MOCA的函数预测了随后的时间估计。我们的数据表明，受损的线索诱发的中额叶~ 4hz活动预示着PD患者认知功能障碍的时间变异性增加。这些发现将PD相关的认知功能障碍与认知控制的皮层机制联系起来，这可能会促进PD的新生物标志物和神经调节。
Patients with Parkinson’s disease (PD) can have significant cognitive dysfunction; however, the mechanisms for these cognitive symptoms are unknown. Here, we used scalp electroencephalography (EEG) to investigate the cortical basis for PD-related cognitive impairments during interval timing, which requires participants to estimate temporal intervals of several seconds. Time estimation is an ideal task demand for investigating cognition in PD because it is simple, requires medial frontal cortical areas, and recruits basic executive processes such as working memory and attention. However, interval timing has never been systematically studied in PD patients with cognitive impairments. We report three main findings. First, 71 PD patients had increased temporal variability compared to 37 demographically matched controls, and this variability correlated with cognitive dysfunction as measured by the Montreal Cognitive Assessment (MOCA). Second, PD patients had attenuated ~4 Hz EEG oscillatory activity at midfrontal electrodes in response to the interval-onset cue, which was also predictive of MOCA. Finally, trial-by-trial linear mixed-effects modeling demonstrated that cue-triggered ~4 Hz power predicted subsequent temporal estimates as a function of PD and MOCA. Our data suggest that impaired cue-evoked midfrontal ~4 Hz activity predicts increased timing variability that is indicative of cognitive dysfunction in PD. These findings link PD-related cognitive dysfunction with cortical mechanisms of cognitive control, which could advance novel biomarkers and neuromodulation for PD.
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