Clonal diversity of Ureaplasma species and its relationship with oligozoospermia and semen quality in Chinese infertile males
Clonal diversity of Ureaplasma species and its relationship with oligozoospermia and semen quality in Chinese infertile males
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中国不育男性解脲支原体克隆多样性及其与少精症和精液质量的关系
DOI：
10.1007/s10096-018-3331-6
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发表时间：
2018-07
影响因子：
4.5
通讯作者：
Xie Xinyou
中科院分区：
文献类型：
--
作者：
Yang Ting;Zou Yanping;Zhou Weili;Ruan Zhi;Kong Yingying;Zhou Yunheng;Zhang Jun;Xie Xinyou
是否存在脲原体属男性不育症的病因仍然存在争议。关于脲原体属的既往研究和男性不育症一直局限于脲原体的物种水平。目前，已建立了一个扩展的多位点序列分型（eMLST）方案，具有较高的区分能力。本研究的目的是使用eMLST来探索脲原体属的分布。分析其在少精子症及精液质量中的作用。从中国不育男性中共获得480份精液样本。脲原体属之间的关联。对少精子症患者的精液特征进行了进一步评估。系统发育分析表明，102个脲原体属。可以分为两个集群和七个子组。在第一组（U. parvum）、eST 16和eST 41是最常见的克隆。第二组（U. eST 82和eST 147是最流行的克隆。亚组A和C属于集群I和亚组1属于集群II显示出与少精子症，在对比脲原体属。阴性组（P < 0.05）。与阴性对照组相比，亚组2的精子活动率降低，尤其是非前向运动（P < 0.05）。这些结果表明，A和C亚群属于集群I（U。parvum）和亚群1（U.解脲支原体）与少精子症有关。属于第二组的第二亚组可能有能力损害精子运动，特别是非前向运动。
Whether Ureaplasma spp. are a causative agent of male infertility remains controversial. Previous studies concerning Ureaplasma spp. and male infertility have been confined to the species level of Ureaplasma. Currently, an expanded multilocus sequence typing (eMLST) scheme has been established with high discriminatory power. The aim of this study was to use eMLST to explore the distribution of Ureaplasma spp. and to analyze its role in oligozoospermia and semen quality. A total of 480 semen samples were obtained from Chinese infertile males. The associations between Ureaplasma spp. with oligozoospermia and semen characteristics were further evaluated. Phylogenetic analysis revealed that 102 Ureaplasma spp. could be separated into two clusters and seven sub-groups. Within cluster I (U. parvum), eST16 and eST41 were the most frequent clones. For cluster II (U. urealyticum), eST82 and eST147 were the most prevalent clones. Sub-groups A and C belonging to cluster I and sub-group 1 belonging to cluster II showed an association with oligozoospermia, in contrast with the Ureaplasma spp. negative group (P < 0.05). Compared with the negative group, semen motility decreased in sub-group 2, especially for non-progressive motility (P < 0.05). These results indicated that sub-groups A and C belonging to cluster I (U. parvum) and sub-group 1 belonging to cluster II (U. urealyticum) were shown to be associated with oligozoospermia. Sub-group 2 belonging to cluster II may have the ability to impair semen motility, especially for non-progressive motility.
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影响因子：
2.9
作者：
Wang, Yan;Liang, Cui-Ling;Gao, Er-Sheng
通讯作者：
Gao, Er-Sheng
DOI：
10.1016/j.jmii.2016.09.004
发表时间：
2018-12-01
影响因子：
7.4
作者：
Zhou, Yun Heng;Ma, Hong Xia;Liu, Yang
通讯作者：
Liu, Yang
中国男性患者和不孕夫妇临床分离解脲支原体的克隆和分布
影响因子：
3.7
作者：
Ruan Z;Yang T;Shi X;Kong Y;Xie X;Zhang J
通讯作者：
Zhang J
影响因子：
3.7
作者：
Zhang J;Kong Y;Ruan Z;Huang J;Song T;Song J;Jiang Y;Yu Y;Xie X
通讯作者：
Xie X
影响因子：
3.6
作者：
Reichart, M;Kahane, I;Bartoov, B
通讯作者：
Bartoov, B