High circadian stimulus lighting therapy for depression: Meta-analysis of clinical trials.
High circadian stimulus lighting therapy for depression: Meta-analysis of clinical trials.
复制标题
DOI：
10.3389/fnins.2022.975576
复制
发表时间：
2022
影响因子：
4.3
通讯作者：
Lin, Yandan
中科院分区：
文献类型：
--
作者：
Zhou, Li;Hou, Dandan;Wang, Yang;Zhou, Sicong;Lin, Yandan
尽管亮光疗法（BLT）已广泛应用于抑郁症的临床治疗，但其抗抑郁作用尚不清楚。考虑到抑郁症和昼夜节律紊乱之间的联系，我们假设与光照水平和光谱相比，人类昼夜节律光转导模型在评估BLT对抑郁症的疗效方面可能更准确。进行了系统回顾和荟萃分析，并使用CS（昼夜节律刺激）模型来量化BLT中照明的功效。在科克伦、EMBASE、MEDLINE和Web of Science中检索了截至2022年6月发表的文章。随机临床试验包括使用高昼夜节律刺激（H-CS，CS > 0.1）作为抑郁症患者与对照组（CS < 0.1）的照明疗法的文章。通过计算平均差（MD）和95%置信区间（CI）估计治疗效果。涉及258名受试者的7项试验符合纳入标准。在这个样本量中，H-CS照明与抑郁症状的显着减少相关（MD =-5.56，95%CI =-9.22至1.90，P = 0.003，I2 = 64%）。根据荟萃分析，CS可用于BLT治疗抑郁症患者的临床评价，暴露于H-CS照明可显著降低成年人的抑郁症状。获得CS > 0.57的范围，在此期间，不同的照明参数组合（例如，光水平、光谱、持续时间和光分布）可以实现对抑郁症的更好治疗。https://www.crd.york.ac.uk/prospero/display_record.php? ID=CRD42021253648。
Although bright light therapy (BLT) has been widely used in the clinical treatment of depression, the antidepressant effect of BLT is not well understood. Considering the connection between depression and disrupted circadian rhythm, we assumed the model of human circadian phototransduction could be more accurate in evaluating the efficacy of BLT for depression compared to light level and spectrum. A systematic review and meta-analysis were conducted and the CS (circadian stimulus) model was used to quantify the efficacy of lighting in BLT. Articles published up to June 2022 were searched in COCHRANE, EMBASE, MEDLINE, and Web of Science. Randomized clinical trials included articles using high circadian stimulus (H-CS, CS > 0.1) as lighting therapy for people with depressive disorder vs. a control group (CS < 0.1). The treatment effect was estimated by calculating the mean difference (MD) with 95% confidence intervals (CIs). Seven trials involving 258 participants met the inclusion criteria. In this sample size, H-CS lighting was associated with a significant reduction in depressive symptoms (MD = −5.56, 95% CI = −9.22 to −1.90, P = 0.003, I2 = 64%). According to the meta-analysis, CS can be employed for the clinical evaluation of BLT for patients with depressive disorder and exposure to H-CS lighting significantly reduced depressive symptoms among adults. A range of CS > 0.57 was obtained, during which different lighting parameter combinations (e.g., light levels, spectra, duration, and light distribution) could achieve better treatment for depression. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021253648.
登录
查看更多内容
影响因子：
6.7
作者：
Anderson, J. L.;Glod, C. A.;Lockley, S. W.
通讯作者：
Lockley, S. W.
影响因子：
5.3
作者：
Benedetti, F;Colombo, C;Smeraldi, E
通讯作者：
Smeraldi, E
影响因子：
6.6
作者：
Meesters, Ybe;Duijzer, Wianne B.;Hommes, Vanja
通讯作者：
Hommes, Vanja
影响因子：
9.8
作者：
Brown TM;Brainard GC;Cajochen C;Czeisler CA;Hanifin JP;Lockley SW;Lucas RJ;Münch M;O'Hagan JB;Peirson SN;Price LLA;Roenneberg T;Schlangen LJM;Skene DJ;Spitschan M;Vetter C;Zee PC;Wright KP Jr
通讯作者：
Wright KP Jr
影响因子：
5.6
作者：
McClung, Colleen A.
通讯作者：
McClung, Colleen A.