Pilot test and validation of the peak day method of prospective determination of ovulation against a handheld urine hormone monitor.
Pilot test and validation of the peak day method of prospective determination of ovulation against a handheld urine hormone monitor.
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DOI：
10.1186/1472-6874-14-4
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发表时间：
2014-01-08
期刊：
影响因子：
--
通讯作者：
Stanford JB
中科院分区：
文献类型：
--
作者：
Porucznik CA;Cox KJ;Schliep KC;Stanford JB
短暂暴露可能会影响生育能力和早期胚胎发育。为了评估体内受孕时间并进行同步生物监测，必须前瞻性地确定排卵。我们报告了一种简单的前瞻性方法（峰值日法）的开发和验证，该方法可根据宫颈液的日常观察来确定可能的排卵日。我们招募了 98 名女性从手册中学习高峰日方法，其中 26 名女性同时使用该方法并进行盲法每日尿激素监测（雌酮葡萄糖醛酸和黄体生成素）。所有女性都被要求在确定排卵后立即完成暴露调查问卷。简而言之，暴露调查问卷捕获了随时间变化和瞬时的暴露，例如药物使用、饮水量和睡眠时间。我们评估了暴露调查问卷的及时完成情况、女性预计排卵日 (EDO) 与专家评审的 EDO 的一致性，以及专家评审和盲法尿液监测的 EDO 之间的一致性。在评估的 147 个周期中，女性在 130 个周期（88%）中选择了 EDO，随后在 122 个周期（94%）中完成了排卵期暴露调查问卷。在用盲法激素监测评估的 26 个周期中，基于宫颈液的峰值日“最佳质量”算法确定了 24 个周期中尿液监测器的排卵±±3 天（92%）。通过简单的书面说明，女性可以确定预计排卵日并进行排卵期暴露评估。高峰日方法具有很高的成本效益，研究人员可以应用它来进行围孕期或早期发育阶段的暴露评估。
Transient exposures may influence fertility and early embryonic development. To assess the time of conception in vivo and conduct concurrent biomonitoring, ovulation must be identified prospectively. We report on the development and validation of a simple, prospective method, the Peak Day method, to determine likely day of ovulation based upon daily observations of cervical fluid. We recruited 98 women to learn the Peak Day method from a brochure, 26 of whom concurrently used the method with blinded daily urine hormone monitoring (estrone glucuronide and luteinizing hormone). All women were instructed to complete an exposure questionnaire immediately upon identifying ovulation. Briefly, the exposure questionnaire captured time-varying and transient exposures such as medication use, water consumption, and amount of sleep. We assessed timely completion of the exposure questionnaire, agreement of women’s estimated day of ovulation (EDO) and the EDO by expert review, and agreement between the EDO by expert review and by blinded urine monitoring. Of 147 cycles evaluated, women selected an EDO in 130 (88%) and subsequently completed the periovulatory exposure questionnaire in 122 (94%) cycles. Of the 26 cycles evaluated with blinded hormonal monitoring, the Peak Day “best quality” algorithm, based upon cervical fluid, identified ovulation ± 3 days of the urine monitor in 24 cycles (92%). With simple written instructions, women can identify an estimated day of ovulation and perform periovulatory exposure assessment. The Peak Day method is highly cost-effective and could be applied by researchers to target periconceptional or very early developmental stage exposure assessment.
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DOI：
10.1186/1476-069x-11-42
发表时间：
2012-06-27
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Barouki R;Gluckman PD;Grandjean P;Hanson M;Heindel JJ
通讯作者：
Heindel JJ
影响因子：
6.1
作者：
Bigelow, JL;Dunson, DB;Colombo, B
通讯作者：
Colombo, B
影响因子：
5.6
作者：
Brender, Jean D.;Felkner, Marilyn;Henry, Judy P.
通讯作者：
Henry, Judy P.
影响因子：
6.7
作者：
Brezina, Paul R.;Haberl, Elisabeth;Wallach, Edward
通讯作者：
Wallach, Edward
影响因子：
2.8
作者：
Campbell, Kenneth L.;Rockett, John C.
通讯作者：
Rockett, John C.