Does cardiorespiratory fitness modify the association between birth weight and insulin resistance in adult life?
Does cardiorespiratory fitness modify the association between birth weight and insulin resistance in adult life?
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DOI：
10.1371/journal.pone.0073967
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Higuchi M
中科院分区：
文献类型：
--
作者：
Aoyama T;Tsushita K;Miyatake N;Numata T;Miyachi M;Tabata I;Cao ZB;Sakamoto S;Higuchi M
较低的出生体重与晚年较高的胰岛素抵抗有关。本研究的目的是确定心肺健康是否会改变成人出生体重与胰岛素抵抗的关联。受试者为 1943 年之后出生的 379 名日本人（137 名男性，242 名女性），年龄在 20-64 岁之间。使用胰岛素抵抗稳态模型评估 (HOMA-IR) 来评估胰岛素抵抗，该模型根据空腹血糖和胰岛素水平计算得出。心肺健康（最大摄氧量，VO2max）通过自行车测力计上的最大分级运动测试进行评估。出生体重根据母婴健康手册记录或受试者或其母亲的记忆报告。多元线性回归分析显示，出生体重与 HOMA-IR 呈负相关（β = −0.141，p = 0.003），即使在调整性别、年龄、当前体重指数、平均血压、甘油三酯、HDL 胆固醇和吸烟状况后也是如此。尽管 VO2max (β = −0.376, p<0.001) 比出生体重更能预测 HOMA-IR，但进一步调整 VO2max 对出生体重和 HOMA-IR 之间的关系影响不大 (β = −0.148, p = 0.001)。结果表明，较低出生体重与较高胰岛素抵抗之间的关联几乎不受成年后心肺健康的影响。然而，心肺健康被发现比出生体重更能预测胰岛素抵抗，这表明增加心肺健康可能比个体的低出生体重在预防胰岛素抵抗方面发挥更重要的作用。
Lower birth weight is associated with higher insulin resistance in later life. The aim of this study was to determine whether cardiorespiratory fitness modifies the association of birth weight with insulin resistance in adults. The subjects were 379 Japanese individuals (137 males, 242 females) aged 20–64 years born after 1943. Insulin resistance was assessed using a homeostasis model assessment of insulin resistance (HOMA-IR), which is calculated from fasting blood glucose and insulin levels. Cardiorespiratory fitness (maximal oxygen uptake, VO2max) was assessed by a maximal graded exercise test on a cycle ergometer. Birth weight was reported according to the Maternal and Child Health Handbook records or the subject’s or his/her mother’s memory. The multiple linear regression analysis revealed that birth weight was inversely associated with HOMA-IR (β = −0.141, p = 0.003), even after adjustment for gender, age, current body mass index, mean blood pressure, triglycerides, HDL cholesterol, and smoking status. Further adjustments for VO2max made little difference in the relationship between birth weight and HOMA-IR (β = −0.148, p = 0.001), although VO2max (β = −0.376, p<0.001) was a stronger predictor of HOMA-IR than birth weight. The results showed that the association of lower birth weight with higher insulin resistance was little modified by cardiorespiratory fitness in adult life. However, cardiorespiratory fitness was found to be a stronger predictor of insulin resistance than was birth weight, suggesting that increasing cardiorespiratory fitness may have a much more important role in preventing insulin resistance than an individual’s low birth weight.
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