Comparing cortisol, stress, and sensory sensitivity in children with autism.
Comparing cortisol, stress, and sensory sensitivity in children with autism.
复制标题
比较自闭症儿童的皮质醇，压力和感觉敏感性。
DOI：
10.1002/aur.64
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发表时间：
2009-02
期刊：
影响因子：
4.7
通讯作者：
Mendoza, Sally
中科院分区：
文献类型：
--
作者：
Corbett, Blythe A.;Schupp, Clayton W.;Levine, Seymour;Mendoza, Sally
以前我们报道过自闭症儿童的皮质醇表现出显著的变异性。目前的研究旨在通过探索皮质醇与压力和感觉功能的心理测量之间的合理关系来扩展这些发现。将患有和不患有自闭症的儿童的昼夜节律和对压力的反应的唾液皮质醇值与父母报告的儿童压力，压力调查表（SSS），感觉功能，短感觉剖面（SSP）和养育压力（PSI）的测量进行比较。在自闭症中，早晨皮质醇和SSS之间的负相关表明，较高的压力症状与较低的皮质醇有关。低皮质醇见于慢性压力和社会关系不稳定的社会情况。感觉灵敏度描绘了一幅更复杂的画面，因为SSP的某些方面与较高的皮质醇有关，而其他方面则与较低的皮质醇有关。我们建议，增加感官灵敏度可能会提高自闭症儿童的易感性的影响，反映在变量皮质醇分泌的zeitgeibers。晚上皮质醇与SSS呈正相关，晚上皮质醇水平越高，孩子的父母报告的日常压力越高，特别是改变，如日常生活。关于对压力的反应，心理和父母的变量没有区分的群体，相反，离散的皮质醇反应者和非反应者的亚组，揭示了自闭症和神经型儿童。研究结果支持自闭症患者的生理和行为压力与感觉敏感性之间存在复杂的相互作用，以及影响各组压力反应的合理发展因素。
Previously we reported that children with autism show significant variability in cortisol. The current investigation was designed to extend these findings by exploring plausible relationships between cortisol and psychological measures of stress and sensory functioning. Salivary cortisol values for diurnal rhythms and response to stress in children with and without autism were compared to parent-report measures of child stress, the Stress Survey Schedule (SSS), sensory functioning, Short Sensory Profile (SSP) and parenting stress (PSI). In autism, a negative relationship between morning cortisol and the SSS revealed that higher observed symptoms of stress were related to lower cortisol. Lower cortisol is seen in conditions of chronic stress and in social situations characterized by unstable social relationships. Sensory sensitivity painted a more complicated picture, in that some aspects of SSP were associated with higher while others were associated with lower cortisol. We propose that increased sensory sensitivity may enhance the autistic child’s susceptibility to the influence of zeitgeibers reflected in variable cortisol secretion. Evening cortisol were positively associated with SSS such that the higher the level of evening cortisol, the higher the child’s parent-reported daily stress, especially to changes, such as in daily routine. Regarding the response to stress, the psychological and parent variables did not differentiate the groups; rather, discrete subgroups of cortisol responders and non-responders were revealed in both the autism and neurotypical children. The results support a complex interplay between physiological and behavioral stress and sensory sensitivity in autism and plausible developmental factors influencing stress reactivity across the groups.
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