Evoked K-complexes and altered interaction between the central and autonomic nervous systems during sleep in alcohol use disorder.
Evoked K-complexes and altered interaction between the central and autonomic nervous systems during sleep in alcohol use disorder.
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DOI：
10.1016/j.alcohol.2019.09.005
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发表时间：
2020-05
期刊：
影响因子：
2.3
通讯作者：
Colrain, Ian M.
中科院分区：
文献类型：
--
作者：
Willoughby, Adrian R.;de Zambotti, Massimiliano;Baker, Fiona C.;Colrain, Ian M.
有证据表明，长期饮酒会损害中枢神经系统(CNS)和自主神经系统(ANS)的功能。虽然这些损害持续到禁欲，但在睡眠期间，这两个系统的功能都已部分恢复。为了研究与皮质CNS反应相关的潜在ANS功能障碍(CNS-ANS偶联障碍)，我们评估了16名近期戒酒使用障碍(AUD)患者(41.6±8.5岁)和13名性别和年龄匹配的对照组参与者(46.6±9.3岁)在稳定的氮气非快速眼动(NREM)睡眠期间，心率(HR)与音调波动相关的K-复合波(KC)。整夜记录脑电(EEG)和心电图(ECG)数据。同时对AUD患者进行饮酒问卷调查。在音调呈现前，AUD患者与对照组相比，心率升高。AUD组与对照组相比，AUD组与KCs相关的HR波动幅度明显较小，且有延迟的趋势，随后的减速也较小。在两组中，当KC产生时HR增加更大且发生得更早，并且KC效应的大小在两组之间没有差异。在AUD患者中，与音调引起的KCs相关的心率时相改变是受损的，反映出ANS功能障碍可能是由心脏迷走神经运输的改变引起的。然而，只有HR反应的时间被发现与澳大利亚人估计的终生饮酒量有关。这些新发现的临床意义和影响需要确定。
There is evidence for impairment in both central nervous system (CNS) and autonomic nervous system (ANS) function with prolonged alcohol use. While these impairments persist into abstinence, partial recovery of function has been demonstrated in both systems during sleep. To investigate potential ANS dysfunction associated with cortical CNS responses (impairment in CNS-ANS coupling), we assessed phasic heart rate (HR) fluctuation associated with tones that did and those that did not elicit a K-complex (KC) during stable N2 non-rapid eye movement (NREM) sleep in a group of 16 recently abstinent alcohol use disorder (AUD) patients (41.6 ± 8.5 years) and a group of 13 sex- and age-matched control participants (46.6 ± 9.3 years). Electroencephalogram (EEG) and electrocardiogram (ECG) data were recorded throughout the night. Alcohol consumption questionnaires were also administered to the AUD patients. AUD patients had elevated HR compared to controls at baseline prior to tone presentation. The HR fluctuation associated with KCs elicited by tone presentation was significantly smaller in amplitude, and tended to be delayed in time, in the AUD group compared with the control group, and the subsequent deceleration was also smaller in AUD patients. In both groups, the increase in HR was larger and occurred earlier when KCs were produced than when they were not, and there was no difference in the magnitude of the KC effect between groups. Phasic HR changes associated with KCs elicited by tones are impaired in AUD participants, reflecting ANS dysfunction possibly caused by an alteration of cardiac vagal trafficking. However, only the timing of the HR response was found to relate to estimated lifetime alcohol consumption in AUD. The clinical meaning and implications of these novel findings need to be determined.
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影响因子：
2.3
作者：
de Zambotti, Massimiliano;Willoughby, Adrian R.;Baker, Fiona C.;Sugarbaker, David S.;Colrain, Ian M.
通讯作者：
Colrain, Ian M.
睡眠唤起的三角洲频率反应显示，整个成人寿命的振幅线性下降。
影响因子：
4.2
作者：
Colrain, Ian M.;Crowley, Kate E.;Nicholas, Christian L.;Afifi, Lamia;Baker, Fiona C.;Padilla, Mayra;Turlington, Sharon R.;Trinder, John
通讯作者：
Trinder, John
影响因子：
3.4
作者：
Colrain IM;Padilla ML;Baker FC
通讯作者：
Baker FC
DOI：
10.1111/acer.12384
发表时间：
2014-05
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
de Zambotti M;Baker FC;Sugarbaker DS;Nicholas CL;Trinder J;Colrain IM
通讯作者：
Colrain IM
影响因子：
5.1
作者：
BARTER, F;TANNER, AR
通讯作者：
TANNER, AR