Innovative cationic fullerenes as broad-spectrum light-activated antimicrobials.
Innovative cationic fullerenes as broad-spectrum light-activated antimicrobials.
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DOI：
10.1016/j.nano.2009.10.005
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发表时间：
2010-06
影响因子：
5.4
通讯作者：
Hamblin, Michael R.
中科院分区：
文献类型：
--
作者：
Huang, Liyi;Terakawa, Mitsuhiro;Zhiyentayev, Timur;Huang, Ying-Ying;Sawayama, Yohei;Jahnke, Ashlee;Tegos, George P.;Wharton, Tim;Hamblin, Michael R.
关键词：
光动力灭活（PDI）是一种快速发展的抗微生物技术，其将无毒的光活化染料或光敏剂（PS）与正确波长的无害可见光组合以激发染料至其反应性三重态，然后产生对细胞具有高度毒性的活性氧物质（ROS）。巴克敏斯特富勒烯是完全由sp2杂化碳原子组成的闭笼分子，虽然它们的主要吸收是在紫外线下，但它们也吸收可见光，并具有长寿命的三重态。当C60富勒烯用阳离子官能团衍生化时，它形成更具水溶性的分子，并且可以在光照下有效地介导PDT，此外阳离子富勒烯可以选择性地结合微生物细胞。在这份报告中，我们描述了几个新的阳离子富勒烯的合成和表征。它们作为广谱抗微生物光敏剂对革兰氏阳性菌，革兰氏阴性菌和真菌酵母的相对有效性通过定量结构功能关系测定。
Photodynamic inactivation (PDI) is a rapidly developing antimicrobial technology which combines a non-toxic photoactivatable dye or photosensitizer (PS) in combination with harmless visible light of the correct wavelength to excite the dye to its reactive triplet state that will then generate reactive oxygen species (ROS) that are highly toxic to cells. Buckminsterfullerenes are closed-cage molecules entirely composed of sp2 hybridized carbon atoms and although their main absorption is in the UV, they also absorb visible light and have a long-lived triplet state. When C60 fullerene is derivatized with cationic functional groups it forms molecules that are more water-soluble and can mediate PDT efficiently upon illumination, and moreover cationic fullerenes can selectively bind to microbial cells. In this report we describe the synthesis and characterization of several new cationic fullerenes. Their relative effectiveness as broad-spectrum antimicrobial photosensitizers against Gram-positive, Gram-negative bacteria, and a fungal yeast was determined by quantitative structure function relationships.
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DOI：
10.1039/b809624d
发表时间：
2009-06
期刊：
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
影响因子：
--
作者：
George S;Hamblin MR;Kishen A
通讯作者：
Kishen A
通过阳离子中二取代的卟啉对革兰氏阴性和革兰氏阳性细菌的光活化的电荷效应。
影响因子：
4.2
作者：
Alves E;Costa L;Carvalho CM;Tomé JP;Faustino MA;Neves MG;Tomé AC;Cavaleiro JA;Cunha A;Almeida A
通讯作者：
Almeida A
影响因子：
11.4
作者：
Jafvert, Chad T.;Kulkarni, Pradnya P.
通讯作者：
Kulkarni, Pradnya P.
影响因子：
2.6
作者：
Mitik-Dineva, Natasa;Wang, James;Ivanova, Elena P.
通讯作者：
Ivanova, Elena P.
影响因子：
3.1
作者：
HAZEN, KC;BRAWNER, DL;CUTLER, JE
通讯作者：
CUTLER, JE