Epidemiology of Renal Cell Carcinoma.
Epidemiology of Renal Cell Carcinoma.
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DOI：
10.1016/j.eururo.2018.08.036
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发表时间：
2019-01
期刊：
影响因子：
23.4
通讯作者：
Russo P
中科院分区：
文献类型：
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作者：
Capitanio U;Bensalah K;Bex A;Boorjian SA;Bray F;Coleman J;Gore JL;Sun M;Wood C;Russo P
尽管在过去的20年里，肾细胞癌（RCC）的诊断和治疗有所改善，但RCC仍然是最致命的泌尿系统恶性肿瘤之一。随着许多疾病的常规成像的扩展，越来越多的患者谁港肾细胞癌被偶然确定。总结和比较肾细胞癌的发病率和死亡率，分析危险因素的大小，并在筛查和疾病管理的背景下解释这些流行病学观察结果。本综述的主要目的是检索和描述全球RCC发病率/死亡率。其次，对已知风险因素的程度进行了叙述性文献综述。最后，从前两个步骤中检索的数据进行了阐述，以确定RCC筛查的临床意义。肾细胞癌的发病率和死亡率在各个国家和世界各地区之间存在显著差异。潜在的RCC风险因素包括行为和环境因素、合并症和镇痛药。吸烟、肥胖、高血压和慢性肾脏疾病是确定的危险因素。其他因素与RCC风险增加有关，尽管可能存在选择偏倚，并且报告了有争议的结果。RCC的发病率在世界范围内各不相同。在确定的几个RCC风险因素中，吸烟、肥胖和高血压与RCC的相关性最强。在RCC风险较高的个体中，由于发病率和死亡率、成本和管理影响的地理异质性，筛查方案的成本效益需要在特定国家水平上进行评估。由于肾细胞癌发病率低，似乎必须采用准确的生物标志物。在发达国家、吸烟者、肥胖者和高血压患者中，肾癌的发病率较高。
Despite the improvement in renal cell carcinoma (RCC) diagnosis and management observed during the last 2 decades, RCC remains one of the most lethal urological malignancies. With the expansion of routine imaging for many disorders, an increasing number of patients who harbour RCC are identified incidentally. To summarise and compare RCC incidence and mortality rates, analyse the magnitude of risk factors, and interpret these epidemiological observations in the context of screening and disease management. The primary objective of the current review was to retrieve and describe worldwide RCC incidence/mortality rates. Secondly, a narrative literature review about the magnitude of the known risk factors was performed. Finally, data retrieved from the first two steps were elaborated to define the clinical implications for RCC screening. RCC incidence and mortality significantly differ among individual countries and world regions. Potential RCC risk factors include behavioural and environmental factors, comorbidities, and analgesics. Smoking, obesity, hypertension, and chronic kidney disease represent established risk factors. Other factors have been associated with an increased RCC risk, although selection biases may be present and controversial results have been reported. Incidence of RCC varies worldwide. Within the several RCC risk factors identified, smoking, obesity, and hypertension are most strongly associated with RCC. In individuals at a higher risk of RCC, the cost effectiveness of a screening programme needs to be assessed on a country-specific level due to geographic heterogeneity in incidence and mortality rates, costs, and management implications. Owing to the low rates of RCC, implementation of accurate biomarkers appears to be mandatory. The probability of harbouring kidney cancer is higher in developed countries and among smokers, obese individuals, and individuals with hypertension.
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影响因子：
5
作者：
Lee, Jung Eun;Hankinson, Susan E.;Cho, Eunyoung
通讯作者：
Cho, Eunyoung
影响因子：
6.4
作者：
Choueiri, Toni K.;Je, Youjin;Cho, Eunyoung
通讯作者：
Cho, Eunyoung
影响因子：
8.8
作者：
Behrens G;Leitzmann MF
通讯作者：
Leitzmann MF
影响因子：
16.2
作者：
Joh HK;Willett WC;Cho E
通讯作者：
Cho E
影响因子：
8.8
作者：
通讯作者：
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