Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents.
Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents.
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DOI：
10.1016/j.yhbeh.2018.04.013
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发表时间：
2018-08
影响因子：
3.5
通讯作者：
Kim J
中科院分区：
文献类型：
--
作者：
Frick KM;Kim J
尽管几十年来人们一直观察到 17β-雌二醇 (E2) 和黄体酮对细胞功能的快速影响，但近年来大量数据证明了这些作用对认知的重要性。特别是，新兴文献表明，这些激素通过快速激活许多细胞事件（包括细胞信号传导、组蛋白修饰和海马体中的局部蛋白质翻译）来促进啮齿类动物空间和物体识别记忆的巩固。本文概述了 E2 和黄体酮增强雌性啮齿类动物海马记忆巩固的证据，然后讨论了迄今为止显示的调节这些激素对记忆形成有益作用的多种分子机制。
Although rapid effects of 17β-estradiol (E2) and progesterone on cellular functions have been observed for several decades, a proliferation of data in recent years has demonstrated the importance of these actions to cognition. In particular, an emerging literature has demonstrated that these hormones promote the consolidation of spatial and object recognition memories in rodents via rapid activation of numerous cellular events including cell signaling, histone modifications, and local protein translation in the hippocampus. This article provides an overview of the evidence demonstrating that E2 and progesterone enhance hippocampal memory consolidation in female rodents, and then discusses numerous molecular mechanisms thus far shown to mediate the beneficial effects of these hormones on memory formation.
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