Tetrapleura tetraptera spice attenuates high-carbohydrate, high-fat diet-induced obese and type 2 diabetic rats with metabolic syndrome features.
Tetrapleura tetraptera spice attenuates high-carbohydrate, high-fat diet-induced obese and type 2 diabetic rats with metabolic syndrome features.
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DOI：
10.1186/s12944-015-0051-0
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发表时间：
2015-05-24
影响因子：
4.5
通讯作者：
Abdul Manan Bin Wan Muda W
中科院分区：
文献类型：
--
作者：
Kuate D;Kengne AP;Biapa CP;Azantsa BG;Abdul Manan Bin Wan Muda W
Tetrapleura tetraptera是一种调味品和营养香料，也用于西非民间医学，用于治疗各种疾病，包括糖尿病，炎症和高血压。黄酮和皂甙是该植物果实中含量丰富的次生代谢成分。本研究旨在评估这种水果富含多酚的水乙醇提取物（HET）在实验诱导的肥胖和2型糖尿病大鼠（T2 DM）特征性代谢综合征（MetS）中的潜在治疗作用。通过高碳水化合物、高脂肪饮食和低剂量链脲佐菌素诱导大鼠MetS。然后给T2 DM大鼠口服不同剂量的HET（200和400 mg/kg），持续28天。使用标准抗糖尿病药物二甲双胍（300 mg/kg）进行比较。然后评估体重、收缩压、氧化应激和代谢参数以评价HET对MetS的影响。HET降低了大鼠的体重增加、空腹血糖和血浆胰岛素水平以及胰岛素抵抗的稳态模型评估（HOMA-IR），并减轻了肥胖和T2 DM相关的氧化应激和高血压。此外，HET给药后观察到显著的降血脂特性和肝损伤和组织脂肪变性的减轻。HET还通过下调肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、C-反应蛋白（CRP）、瘦素和增加脂联素来显示其抗炎作用。HET表现出与二甲双胍相当的剂量依赖性效应。因此，本研究证明了HET的抗胰岛素抵抗、抗糖尿病、抗肥胖、消肿和抗炎特性;因此，其具有进一步开发用于管理MetS（如肥胖、T2 DM和高血压）的潜力。
Tetrapleura tetraptera, a seasoning and nutritive spice is also used in western African folk medicine in the management of wide variety of diseases including diabetes, inflammation and hypertension. Flavonoids and saponins are some abundant secondary metabolic constituents in the fruits of this plant. This study aimed at evaluating the potential therapeutic action of the polyphenol-rich hydroethanolic extract (HET) of this fruit in experimentally induced obese and type 2 diabetic rats (T2DM) with characteristic metabolic syndrome (MetS). MetS was induced in rats by high-carbohydrate, high-fat diet and administration of low-dose streptozotocin. Then different oral doses of HET (200 and 400 mg/kg) were administered to T2DM rats for 28 days. A standard antidiabetic drug, metformin (300 mg/kg), was used for comparison. The body weight, systolic blood pressure, oxidative stress and metabolic parameters were then assessed to evaluate the effect of HET on MetS. HET reduced weight gain, fasting blood glucose and plasma insulin levels as well as homeostasis model assessment of insulin resistance (HOMA-IR) and alleviated obesity and T2DM associated oxidative stress and hypertension in rats. Moreover, a significantly hypolipidemic property and an attenuation of liver injury and tissue steatosis was observed after HET administration. HET further demonstrated its anti-inflammation effect via down regulation of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), leptin and an increase in adiponectin. The HET exhibited dose-dependent effects which were comparable to that of metformin. The present study thereby demonstrates the anti-insulin resistance, antilipidemic, anti-obesity, hypotensive and anti-inflammatory properties of HET; hence it has the potential to be further developed for the management of MetS such as obesity, T2DM and hypertension.
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影响因子：
4
作者：
ESSIEN, EU;IZUNWANE, BC;EKA, OU
通讯作者：
EKA, OU
影响因子：
3
作者：
Hansen, Dominique;Dendale, Paul;van Loon, Luc J. C.
通讯作者：
van Loon, Luc J. C.
影响因子：
--
作者：
Bansal, Punit;Paul, Piya;Unnikrishnan, M. K.
通讯作者：
Unnikrishnan, M. K.
影响因子：
3.7
作者：
Basu S;Yoffe P;Hills N;Lustig RH
通讯作者：
Lustig RH
影响因子：
5.6
作者：
Jeszka-Skowron, Magdalena;Flaczyk, Ewa;Buchowski, Maciej S.
通讯作者：
Buchowski, Maciej S.