Reference intervals of serum hyaluronic acid corresponding to the radiographic severity of knee osteoarthritis in women.
Reference intervals of serum hyaluronic acid corresponding to the radiographic severity of knee osteoarthritis in women.
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DOI：
10.1186/1471-2474-14-34
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发表时间：
2013-01-18
影响因子：
2.3
通讯作者：
Kaneko K
中科院分区：
文献类型：
--
作者：
Kaneko H;Ishijima M;Doi T;Futami I;Liu L;Sadatsuki R;Yusup A;Hada S;Kubota M;Kawasaki T;Saita Y;Takazawa Y;Ikeda H;Kurosawa H;Kaneko K
虽然已知血清透明质酸（sHA）水平可用于膝关节OA的疾病负担生物标志物，但它远不实用。必须建立生物标志物的参考区间，以便对临床解释有用。本研究的目的是建立与膝关节OA放射学严重程度相对应的sHA的参考区间，以阐明sHA是否可以作为单个膝关节OA患者的疾病负担标记物。372名患有Kellgren & Lawrence级（K/L） 1至4级疼痛性膝关节炎的女性参加了这项研究。其中K/L 1型54例，K/L 2型96例，K/L 3型97例，K/L 4型118例。在拍摄x光片的当天提取所有受试者的血清样本。HA结合蛋白为基础的乳胶凝集试验采用ELISA格式来测量sHA。采用年龄和BMI调整后的单因素方差分析设置sHA的参考区间。K/L 4患者对应的sHA参考区间（49.6 ~ 66.5 ng/ml）与K/L 1、2、3患者无重叠，而K/L 1、2、3患者有相当大的重叠。这些结果表明，sHA可作为严重膝关节OA患者（K/L 4）的疾病负担标志物，而不适用于原发性至中度膝关节OA患者（K/L 1-3）。
While serum levels of hyarulonic acid (sHA) is known to be useful for a burden of disease biomarker in knee OA, it is far from practical. The reference intervals must be established for biomarkers to be useful for clinical interpretation. The aim of this study was to establish the reference intervals of sHA corresponding to the radiographic severity of knee OA for elucidating whether sHA can be useful as a burden of disease marker for individual patient with knee OA. 372 women with Kellgren & Lawrence grade (K/L) 1 through 4 painful knee OA were enrolled in this study. The patients included 54 with K/L 1, 96 with K/L 2, 97 with K/L 3, and 118 with K/L 4. Serum samples were obtained from all subjects on the day that radiographs taken. A HA binding protein based latex agglutination assay that employed an ELISA format was used to measure sHA. Age and BMI adjusted one way ANOVA was used to set the reference intervals of sHA. The reference intervals for sHA corresponding to the patients with K/L 4 (49.6 – 66.5 ng/ml) was established without any overlap against to those with K/L 1, 2 and 3, while those with K/L 1, 2 and 3 showed considerable overlap. These results indicate that sHA can be available as a burden of disease marker for the individuals with severe knee OA (K/L 4), while it is not for those with primary to moderate knee OA (K/L 1–3).
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影响因子：
4.9
作者：
Ishijima M;Watari T;Naito K;Kaneko H;Futami I;Yoshimura-Ishida K;Tomonaga A;Yamaguchi H;Yamamoto T;Nagaoka I;Kurosawa H;Poole RA;Kaneko K
通讯作者：
Kaneko K
DOI：
10.1016/j.berh.2005.09.001
发表时间：
2006-02-01
影响因子：
5.2
作者：
Kraus, VB
通讯作者：
Kraus, VB
DOI：
10.1038/ncprheum0508
发表时间：
2007-06-01
期刊：
NATURE CLINICAL PRACTICE RHEUMATOLOGY
影响因子：
--
作者：
Rousseau, Jean-Charles;Delmas, Pierre D.
通讯作者：
Delmas, Pierre D.
DOI：
10.1002/art.22475
发表时间：
2007-02-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Belo, J. N.;Berger, M. Y.;Bierma-Zeinstra, S. M. A.
通讯作者：
Bierma-Zeinstra, S. M. A.
影响因子：
--
作者：
Elliott, AL;Kraus, VB;Jordan, JM
通讯作者：
Jordan, JM